5N1Y

HLA-A02 carrying MVWGPDPLYV

Replaces:  5C0H

Summary for 5N1Y

Related5HYJ 5C07 5C08 5C09 5C0A 5C0B 5C0D 5COD 5COE 5C0F 5C0G 5C0I 5C0J
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, MVWGPDPLYV, ... (6 entities in total)
Functional Keywordsimmuno, hla-a02, 1e6-tcr, cross-rteactivity, immune system
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted . Note=(Microbial infection) In the presence of M P61769
Total number of polymer chains3
Total molecular weight46127.31
Authors
Rizkallah, P.J.,Bulek, A.M.,Cole, D.K.,Sewell, A.K. (deposition date: 2017-02-06, release date: 2017-02-15)
Primary citation
Cole, D.K.,Bulek, A.M.,Dolton, G.,Schauenberg, A.J.,Szomolay, B.,Rittase, W.,Trimby, A.,Jothikumar, P.,Fuller, A.,Skowera, A.,Rossjohn, J.,Zhu, C.,Miles, J.J.,Peakman, M.,Wooldridge, L.,Rizkallah, P.J.,Sewell, A.K.
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J. Clin. Invest., 126:2191-2204, 2016
PubMed: 27183389 (PDB entries with the same primary citation)
DOI: 10.1172/JCI85679
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.39 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.205902.7%9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5n1y
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Molmil generated image of 5n1y
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Molmil generated image of 5n1y
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