5C0D

HLA-A02 carrying AQWGPDPAAA

Summary for 5C0D

Related5C06 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0E 5C0F 5C0G 5C0I 5C0J 3UTP 3UTQ 3UTS 3UTT 5HYJ 5C0H
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Marker peptide, ... (4 entities in total)
Functional Keywordsimmuno, hla-a02, 1e6-tcr, cross-reactivity, immune system
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted  P61769
Total number of polymer chains3
Total molecular weight44813.71
Authors
Rizkallah, P.J.,Bulek, A.M.,Cole, D.K.,Sewell, A.K. (deposition date: 2015-06-12, release date: 2016-05-04, Last modification date: 2016-06-08)
Primary citation
Cole, D.K.,Bulek, A.M.,Dolton, G.,Schauenberg, A.J.,Szomolay, B.,Rittase, W.,Trimby, A.,Jothikumar, P.,Fuller, A.,Skowera, A.,Rossjohn, J.,Zhu, C.,Miles, J.J.,Peakman, M.,Wooldridge, L.,Rizkallah, P.J.,Sewell, A.K.
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J.Clin.Invest., 126:2191-2204, 2016
PubMed: 27183389 (PDB entries with the same primary citation)
DOI: 10.1172/JCI85679
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.68 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22070.3%3.0%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5c0d
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Molmil generated image of 5c0d
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Molmil generated image of 5c0d
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