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3CN2	Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl Descriptor: 3,5-dibromobiphenyl-4-ol, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2008-03-24 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
2G9K	Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl Descriptor: 2',3,3',4',5-PENTACHLOROBIPHENYL-4-OL, Transthyretin Authors: Palaninathan, S.K, Smith, C, Safe, S.H, Kelly, J.W, Sacchettini, J.C. Deposit date: 2006-03-06 Release date: 2006-03-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Chem.Biol., 11, 2004
3CFT	Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate Descriptor: 5-aminonaphthalene-1-sulfonic acid, Transthyretin Authors: Lima, L.-M.T.R, Foguel, D, Polikarpov, I. Deposit date: 2008-03-04 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3CN0	Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene Descriptor: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2008-03-24 Release date: 2008-10-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
8WGS	Crystal structure of V30M-TTR in complex with compound 4 Descriptor: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-4-iodanyl-1-benzofuran-3-yl)methanone Authors: Yokoyama, T. Deposit date: 2023-09-22 Release date: 2024-05-15 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.801 Å) Cite: Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
8VJV	Structure of Human Neurolysin in complex with dynorphin A8(1-8) peptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dynorphin A(1-8), ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8VJW	Structure of Human Neurolysin in complex with angiotensin I peptide Descriptor: Angiotensin-1 peptide C-terminal end, Angiotensin-1 peptide N-terminal end, Neurolysin, ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Last modified: 2024-09-25 Method: X-RAY DIFFRACTION (2.491 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8WGU	Crystal structure of V30M-TTR in complex with compound 20 Descriptor: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone Authors: Yokoyama, T. Deposit date: 2023-09-22 Release date: 2024-05-15 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.508 Å) Cite: Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
8VJX	Structure of Human Neurolysin in complex with bradykinin peptide Descriptor: Bradykinin, Neurolysin, mitochondrial, ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
8WGT	Crystal structure of V30M-TTR in complex with compound 7 Descriptor: Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone Authors: Yokoyama, T. Deposit date: 2023-09-22 Release date: 2024-05-15 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.696 Å) Cite: Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
8VJU	Structure of Human Neurolysin in complex with dynorphin A13 peptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dynorphin A(1-13), ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
9B1R	Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1 Authors: Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C. Deposit date: 2024-03-13 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana. Sci Rep, 14, 2024
8VJY	Structure of Human Neurolysin in complex with Neurotensin peptide Descriptor: 1,2-ETHANEDIOL, Neurolysin, mitochondrial, ... Authors: Shi, K, Aihara, H. Deposit date: 2024-01-08 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural basis of divergent substrate recognition and inhibition of human neurolysin. Sci Rep, 14, 2024
4PVL	X-ray structure of human transthyretin (TTR) at room temperature to 1.9A resolution Descriptor: Transthyretin Authors: Fisher, S.J, Blakeley, M.P, Haupt, M, Mason, S.A, Cooper, J.B, Mitchell, E.P, Forsyth, V.T. Deposit date: 2014-03-18 Release date: 2014-11-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.851 Å) Cite: Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein IUCrJ, 1, 2014
4PWH	Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester Descriptor: 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.798 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PWI	Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid Descriptor: (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.494 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PWE	Crystal structure of V30M mutant human transthyretin Descriptor: Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PWJ	Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid Descriptor: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PWG	Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester Descriptor: CALCIUM ION, Transthyretin, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.798 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PWK	Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid Descriptor: 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol), Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-03-20 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4PVN	Neutron structure of human transthyretin (TTR) at room temperature to 2.3A resolution (monochromatic) Descriptor: Transthyretin Authors: Fisher, S.J, Blakeley, M.P, Haupt, M, Mason, S.A, Cooper, J.B, Mitchell, E.P, Forsyth, V.T. Deposit date: 2014-03-18 Release date: 2014-11-12 Last modified: 2024-03-20 Method: NEUTRON DIFFRACTION (2.3 Å), X-RAY DIFFRACTION Cite: Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein IUCrJ, 1, 2014
4QYA	Crystal structure of human transthyretin variant V30M in complex with luteolin Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin Authors: Begum, A, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2014-07-24 Release date: 2015-06-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response. Plos One, 10, 2015
4PME	Human transthyretin (TTR) complexed with ferulic acid and curcumin. Descriptor: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... Authors: Stura, E.A, Ciccone, L. Deposit date: 2014-05-21 Release date: 2014-10-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.264 Å) Cite: Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
4QRF	Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester Descriptor: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin Authors: Yokoyama, T, Kosaka, Y, Mizuguchi, M. Deposit date: 2014-06-30 Release date: 2014-11-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
4QXV	CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ... Authors: Begum, A, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2014-07-22 Release date: 2015-06-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.12 Å) Cite: The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response. Plos One, 10, 2015

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