8WGS

Crystal structure of V30M-TTR in complex with compound 4

Summary for 8WGS

• Entry DOI: 10.2210/pdb8wgs/pdb
• Descriptor: Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-4-iodanyl-1-benzofuran-3-yl)methanone (3 entities in total)
• Functional Keywords: transthyretin, amyloidosis, inhibitor, benziodarone derivative, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 35973.13

Authors

Yokoyama, T. (deposition date: 2023-09-22, release date: 2024-05-15, Last modification date: 2024-05-29)

• Primary citation: Mizuguchi, M.,Nakagawa, Y.,Yokoyama, T.,Okada, T.,Fujii, K.,Takahashi, K.,Luan, N.N.T.,Nabeshima, Y.,Kanamitsu, K.,Nakagawa, S.,Yamakawa, S.,Ueda, M.,Ando, Y.,Toyooka, N.; Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.; J.Med.Chem., 67:6987-7005, 2024; PubMed: 38670538; DOI: 10.1021/acs.jmedchem.3c02286

Experimental method

X-RAY DIFFRACTION (1.801 Å)