4PWG

Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester

Summary for 4PWG

Entry DOI	10.2210/pdb4pwg/pdb
Related	4PWE 4PWF 4PWH 4PWI 4PWJ 4PWK
Descriptor	Transthyretin, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, ... (4 entities in total)
Functional Keywords	tranporter, thyroxine binding, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	35141.66
Authors	Yokoyama, T.,Kosaka, Y.,Mizuguchi, M. (deposition date: 2014-03-20, release date: 2014-11-26, Last modification date: 2023-11-08)
Primary citation	Yokoyama, T.,Kosaka, Y.,Mizuguchi, M. Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57:8928-8935, 2014 Cited by PubMed: 25314129 DOI: 10.1021/jm500997m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.798 Å)

Structure validation