4PWG

Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (human)	ATTR, Prealbumin, TBPA
2	A, B	ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	non-polymer		208.2	2	Chemie (0XR)
3	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
4		water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	expression tag
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	3
	Total formula weight	456.5
All*	Total formula weight	35141.7

*Water molecules are not included.