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4PWK

Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid

Summary for 4PWK
Entry DOI10.2210/pdb4pwk/pdb
Related4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ
DescriptorTransthyretin, 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) (3 entities in total)
Functional Keywordstransporter, thyroxine binding, transport protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight35346.00
Authors
Yokoyama, T.,Kosaka, Y.,Mizuguchi, M. (deposition date: 2014-03-20, release date: 2014-11-26, Last modification date: 2023-11-08)
Primary citationYokoyama, T.,Kosaka, Y.,Mizuguchi, M.
Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57:8928-8935, 2014
Cited by
PubMed: 25314129
DOI: 10.1021/jm500997m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.59 Å)
Structure validation

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