3CN0
Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene
Summary for 3CN0
| Entry DOI | 10.2210/pdb3cn0/pdb |
| Related | 2QGB 3CN1 3CN2 3CN3 3CN4 |
| Descriptor | Transthyretin, 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol (3 entities in total) |
| Functional Keywords | transthyretin, tetramer, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, hormone, transport protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28003.32 |
| Authors | Connelly, S.,Wilson, I.A. (deposition date: 2008-03-24, release date: 2008-10-28, Last modification date: 2024-02-21) |
| Primary citation | Johnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51:6348-6358, 2008 Cited by PubMed: 18811132DOI: 10.1021/jm800435s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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