4PWH
Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester
Summary for 4PWH
Entry DOI | 10.2210/pdb4pwh/pdb |
Related | 4PWE 4PWF 4PWG 4PWI 4PWJ 4PWK |
Descriptor | Transthyretin, 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | transporter, thyroxine binding, transport protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 35261.87 |
Authors | Yokoyama, T.,Kosaka, Y.,Mizuguchi, M. (deposition date: 2014-03-20, release date: 2014-11-26, Last modification date: 2023-11-08) |
Primary citation | Yokoyama, T.,Kosaka, Y.,Mizuguchi, M. Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57:8928-8935, 2014 Cited by PubMed: 25314129DOI: 10.1021/jm500997m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.798 Å) |
Structure validation
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