4PWH

Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (human)	ATTR, Prealbumin, TBPA
2	A, B	3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate	non-polymer		248.3	2	Chemie (PWH)
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4		water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	expression tag
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	4
	Total formula weight	576.7
All*	Total formula weight	35261.9

*Water molecules are not included.