4PND
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![BU of 4pnd by Molmil](/molmil-images/mine/4pnd) | A de novo designed pentameric coiled coil CC-Pent_Variant | Descriptor: | CC-Pent_Variant | Authors: | Wood, C.W, Burton, A.J, Thomson, A.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2014-05-23 | Release date: | 2014-10-22 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Computational design of water-soluble alpha-helical barrels. Science, 346, 2014
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4PNB
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![BU of 4pnb by Molmil](/molmil-images/mine/4pnb) | A de novo designed hexameric coiled coil CC-Hex3. | Descriptor: | CC-Hex3 | Authors: | Wood, C.W, Burton, A.J, Thomson, A.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2014-05-23 | Release date: | 2014-10-22 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Computational design of water-soluble alpha-helical barrels. Science, 346, 2014
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3LJM
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![BU of 3ljm by Molmil](/molmil-images/mine/3ljm) | Structure of de novo designed apo peptide coil SER L9C | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COIL SER L9C, ... | Authors: | Chakraborty, S. | Deposit date: | 2010-01-26 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Structural comparisons of apo- and metalated three-stranded coiled coils clarify metal binding determinants in thiolate containing designed peptides. J.Am.Chem.Soc., 132, 2010
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6O0I
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![BU of 6o0i by Molmil](/molmil-images/mine/6o0i) | NMR ensemble of computationally designed protein XAA | Descriptor: | Design construct XAA | Authors: | Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D. | Deposit date: | 2019-02-16 | Release date: | 2020-04-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc.Natl.Acad.Sci.USA, 117, 2020
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4ETJ
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![BU of 4etj by Molmil](/molmil-images/mine/4etj) | Crystal Structure of E6H variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR185 | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CHLORIDE ION, ... | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-24 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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4ESS
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![BU of 4ess by Molmil](/molmil-images/mine/4ess) | Crystal Structure of E6D/L155R variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR187 | Descriptor: | OR187 | Authors: | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-04-23 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9971 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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2KIK
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![BU of 2kik by Molmil](/molmil-images/mine/2kik) | |
6C9K
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![BU of 6c9k by Molmil](/molmil-images/mine/6c9k) | Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | Deposit date: | 2018-01-26 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6C9I
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![BU of 6c9i by Molmil](/molmil-images/mine/6c9i) | Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins - Scaffold | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | Deposit date: | 2018-01-26 | Release date: | 2018-03-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7DNS
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![BU of 7dns by Molmil](/molmil-images/mine/7dns) | Crystal structure of domain-swapped dimer of H5_Fold-0 Elsa; de novo designed protein with an asymmetric all-alpha topology | Descriptor: | GLYCEROL, de novo designed protein | Authors: | Suzuki, K, Kobayashi, N, Murata, T, Sakuma, K, Kosugi, T, Koga, R, Koga, N. | Deposit date: | 2020-12-10 | Release date: | 2021-07-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.327 Å) | Cite: | Design of complicated all-alpha protein structures Nat.Struct.Mol.Biol., 2024
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3V45
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![BU of 3v45 by Molmil](/molmil-images/mine/3v45) | Crystal Structure of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium Target OR130 | Descriptor: | CHLORIDE ION, SODIUM ION, Serine hydrolase OSH55 | Authors: | Kuzin, A, Su, M, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-12-14 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol., 10, 2014
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6FDB
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![BU of 6fdb by Molmil](/molmil-images/mine/6fdb) | |
5WP3
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![BU of 5wp3 by Molmil](/molmil-images/mine/5wp3) | Crystal Structure of EED in complex with EB22 | Descriptor: | EB22, Polycomb protein EED, UNKNOWN ATOM OR ION | Authors: | Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2017-08-03 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4J9T
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![BU of 4j9t by Molmil](/molmil-images/mine/4j9t) | Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61 | Descriptor: | ARSENIC, GLYCEROL, designed unnatural amino acid dependent metalloprotein | Authors: | Forouhar, F, Lew, S, Seetharaman, J, Mills, J.H, Khare, S.D, Everett, J.K, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-02-17 | Release date: | 2013-03-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc., 135, 2013
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6VFL
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![BU of 6vfl by Molmil](/molmil-images/mine/6vfl) | |
8ED3
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![BU of 8ed3 by Molmil](/molmil-images/mine/8ed3) | |
5LKA
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![BU of 5lka by Molmil](/molmil-images/mine/5lka) | Crystal structure of haloalkane dehalogenase LinB 140A+143L+177W+211L mutant (LinB86) from Sphingobium japonicum UT26 at 1.3 A resolution | Descriptor: | Haloalkane dehalogenase, THIOCYANATE ION | Authors: | Degtjarik, O, Rezacova, P, Iermak, I, Chaloupkova, R, Damborsky, J, Kuta Smatanova, I. | Deposit date: | 2016-07-21 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.298 Å) | Cite: | Engineering a de novo transport tunnel. Acs Catalysis, 2016
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6KOS
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6TMS
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![BU of 6tms by Molmil](/molmil-images/mine/6tms) | Crystal structure of a de novo designed hexameric helical-bundle protein | Descriptor: | SULFATE ION, a novel designed pore protein, affinity purification tag | Authors: | Xu, C, Pei, X.Y, Luisi, B.F, Baker, D. | Deposit date: | 2019-12-05 | Release date: | 2020-04-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Computational design of transmembrane pores. Nature, 585, 2020
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3O4C
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![BU of 3o4c by Molmil](/molmil-images/mine/3o4c) | |
3O4B
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![BU of 3o4b by Molmil](/molmil-images/mine/3o4b) | |
3O4A
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![BU of 3o4a by Molmil](/molmil-images/mine/3o4a) | |
3O4D
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3OGF
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![BU of 3ogf by Molmil](/molmil-images/mine/3ogf) | |
3OL0
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![BU of 3ol0 by Molmil](/molmil-images/mine/3ol0) | |