PDB: 1138 resultsInfo pagesStatus searchChemie searchBIRD

---

6GRP	Crystal Structure Of Human Transthyretin in complex with 3,5,6-trichloro-2-pyridinol (TC2P) Descriptor: 3,5,6-trichloro-2-pyridinol, SODIUM ION, Transthyretin Authors: Grundstrom, C, Zhang, J, Olofsson, A, Andersson, P.L, Sauer-Eriksson, A.E. Deposit date: 2018-06-12 Release date: 2018-07-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals. Environ. Sci. Technol., 52, 2018
5A6I	V122I Transthyretin structure in complex with Tolcalpone Descriptor: TRANSTHYRETIN, Tolcapone Authors: Reverter, D, Gallego, P, Santana, R, Ventura, S. Deposit date: 2015-06-26 Release date: 2016-02-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7, 2016
5AN3	Structure of an Sgt1-Skp1 Complex Descriptor: SGT1, SUPPRESSOR OF KINETOCHORE PROTEIN 1 Authors: Willhoft, O, Vaughan, C.K. Deposit date: 2015-09-03 Release date: 2017-02-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.82 Å) Cite: The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. Sci Rep, 7, 2017
6GR7	Crystal Structure Of Human Transthyretin in complex with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) Descriptor: 2-[2,4,5-tris(chloranyl)phenoxy]ethanoic acid, Transthyretin Authors: Grundstrom, C, Zhang, J, Olofsson, A, Andersson, P.L, Sauer-Eriksson, A.E. Deposit date: 2018-06-09 Release date: 2018-07-11 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals. Environ. Sci. Technol., 52, 2018
5BOJ	Crystal Structure of Human Transthyretin in Complex with Gemfibrozil Descriptor: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, SODIUM ION, Transthyretin Authors: Begum, A, Olofsson, A, Sauer-Eriksson, A.E. Deposit date: 2015-05-27 Release date: 2015-08-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J.Med.Chem., 58, 2015
6HNR	Trypanosoma brucei PTR1 in complex with the triazine inhibitor 1 (F217) Descriptor: 1-(3,4-dichlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine, ACETATE ION, GLYCEROL, ... Authors: Landi, G, Pozzi, C, Mangani, S. Deposit date: 2018-09-17 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5, 2019
8I00	Crystal structure of A97S transthyretin Descriptor: Transthyretin Authors: Agrawal, S, Yu, T.-Y. Deposit date: 2023-01-10 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure and dynamics of pathogenic transthyretin variant A97S To Be Published
6HNC	Trypanosoma brucei PTR1 in complex with cycloguanil Descriptor: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, ACETATE ION, DIMETHYL SULFOXIDE, ... Authors: Landi, G, Pozzi, C, Mangani, S. Deposit date: 2018-09-14 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5, 2019
4HJS	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
4HIQ	The Structure of V122I Mutant Transthyretin in Complex with AG10 Descriptor: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin Authors: Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. Deposit date: 2012-10-11 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.18 Å) Cite: AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
8I0O	Crystal structure of Transthyretin variant A97S in monomeric form Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Transthyretin Authors: Agrawal, S, Yu, T.-Y. Deposit date: 2023-01-11 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structure and dynamics of Transthyretin pathogenic variant A97S To Be Published
4HIS	The Structure of V122I Mutant Transthyretin in Complex with Tafamidis Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin Authors: Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. Deposit date: 2012-10-11 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJU	Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide Descriptor: N-{3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}prop-2-enamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
6HOW	Trypanosoma brucei PTR1 in complex with the triazine inhibitor 2a (F219). Descriptor: (2~{R})-1-(3,4-dichlorophenyl)-2-(4-nitrophenyl)-2~{H}-1,3,5-triazine-4,6-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase Authors: Landi, G, Pozzi, C, Mangani, S. Deposit date: 2018-09-18 Release date: 2019-05-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5, 2019
4HJT	Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013
1FT4	PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1 Descriptor: 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE, SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1 Authors: Muckelbauer, J.K, Chang, C.-H. Deposit date: 2000-09-11 Release date: 2001-10-12 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc.Natl.Acad.Sci.USA, 98, 2001
4I89	Crystal structure of transthyretin in complex with diflunisal at acidic pH Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin Authors: Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R. Deposit date: 2012-12-03 Release date: 2013-06-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors. Febs Lett., 587, 2013
5CM1	X-ray structure of perdeuterated TTR mutant - T119M at 1.22A Descriptor: Transthyretin Authors: Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. Deposit date: 2015-07-16 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.22 Å) Cite: X-ray structure of perdeuterated TTR mutant - T119M at 1.22A To Be Published
4DEU	Crystal Structure of the Wild Type TTR Binding Naringenin (TTRwt:NAR) Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, NARINGENIN, ... Authors: Trivella, D.B.B, Polikarpov, I. Deposit date: 2012-01-22 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. J.Struct.Biol., 180, 2012
5CLX	X-ray structure of perdeuterated TTR mutant - S52P at 1.28A resolution Descriptor: GLYCEROL, Transthyretin Authors: Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. Deposit date: 2015-07-16 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.28 Å) Cite: X-ray structure of perdeuterated TTR mutant - S52P at 1.28A resolution To Be Published
6IMX	Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6 Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Transthyretin Authors: Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. Deposit date: 2018-10-24 Release date: 2019-03-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
4IKK	Crystal structure of wild-type human transthyretin in complex with sulindac Descriptor: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid Authors: Lima, L.M.T.R. Deposit date: 2012-12-26 Release date: 2013-01-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
5CR1	Crystal structure of TTR/resveratrol/T4 complex Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, RESVERATROL, Transthyretin Authors: Zanotti, G, Florio, P, Folli, C, Cianci, M, Del Rio, D, Berni, R. Deposit date: 2015-07-22 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.545 Å) Cite: Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites. J.Biol.Chem., 290, 2015
4IKL	Crystal structure of wild-type human transthyretin in complex with sulindac Descriptor: Transthyretin, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid Authors: Lima, L.M.T.R, Polikarpov, I. Deposit date: 2012-12-26 Release date: 2013-01-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of wild-type human transthyretin in complex with sulindac To be Published
5AKV	Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: genistein-7-O- glucuronide Descriptor: Genistein-7-O-glucuronide, TRANSTHYRETIN Authors: Florio, P, Foll, C, Cianci, M, Del Rio, D, Zanotti, G, Berni, R. Deposit date: 2015-03-05 Release date: 2015-10-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites J.Biol.Chem., 290, 2015

<27282930313233343536373839404142>