4I89

Crystal structure of transthyretin in complex with diflunisal at acidic pH

Summary for 4I89

Related4I85 4I87
DescriptorTransthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID (3 entities in total)
Functional Keywordsamyloidosis, fibrillogenesis inhibitor, transthyretin stabilizers, t4 or t3 hormone, plasma, transport protein-inhibitor complex, transport protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight28002.96
Authors
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2013-08-07)
Primary citation
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R.
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587:2325-2331, 2013
PubMed: 23792159 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2013.06.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.69 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217130.4%3.1%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4i89
no rotation
Molmil generated image of 4i89
rotated about x axis by 90°
Molmil generated image of 4i89
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4i89
no rotation
Molmil generated image of 4i89
rotated about x axis by 90°
Molmil generated image of 4i89
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4i89.pdb1.gz [84.94 KB])