4I85

Crystal structure of transthyretin in complex with CHF5074 at neutral pH

Summary for 4I85

Related3D2T 1ROX 1DVT 2G3X 1F41 4I89 4I87
DescriptorTransthyretin, 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid (3 entities in total)
Functional Keywordsamyloidosis, fibrillogenesis, amyloid fibrils, t3 or t4 hormone binding, plasma, transport protein-inhibitor complex, transport protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight28205.04
Authors
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2013-08-07)
Primary citation
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R.
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587:2325-2331, 2013
PubMed: 23792159 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2013.06.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.67 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.235701.6%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 4i85
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Molmil generated image of 4i85
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4i85.pdb1.gz [82.46 KB])