4I87

Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH

Summary for 4I87

Related4I85 4I89
DescriptorTransthyretin, 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid (3 entities in total)
Functional Keywordstransthyretin, amyloidosis, fibrillogenesis inhibitors, protein misfolding, t3 or t4 hormone, plasma, transport protein-inhibitor complex, transport protein/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight28152.88
Authors
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R. (deposition date: 2012-12-03, release date: 2013-06-19, Last modification date: 2013-08-07)
Primary citation
Zanotti, G.,Cendron, L.,Folli, C.,Florio, P.,Imbimbo, B.P.,Berni, R.
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587:2325-2331, 2013
PubMed: 23792159 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2013.06.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.69 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21680.4%2.6%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4i87
no rotation
Molmil generated image of 4i87
rotated about x axis by 90°
Molmil generated image of 4i87
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4i87
no rotation
Molmil generated image of 4i87
rotated about x axis by 90°
Molmil generated image of 4i87
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4i87.pdb1.gz [86.84 KB])