4I87
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transthyretin | polymer | 127 | 13751.3 | 2 | UniProt (P02766) Pfam (PF00576) In PDB | Homo sapiens (human) | ATTR, Prealbumin, TBPA |
2 | A, B | 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid | non-polymer | 325.2 | 2 | Chemie (H50) | |||
3 | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 127 (UniProt: P02766)
PDB | External Database | Details |
---|---|---|
Ser 84 | Ile 104 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27502.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 650.3 | |
All* | Total formula weight | 28152.9 |