4HJS

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide

Summary for 4HJS

Entry DOI	10.2210/pdb4hjs/pdb
Related	3HJO 4HJT 4HJU
Descriptor	Transthyretin, N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide (3 entities in total)
Functional Keywords	hormone binding protein, thyroxine, retinol binding protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	26069.29
Authors	Connelly, S.,Wilson, I.A. (deposition date: 2012-10-14, release date: 2013-12-04, Last modification date: 2023-09-20)
Primary citation	Suh, E.H.,Liu, Y.,Connelly, S.,Genereux, J.C.,Wilson, I.A.,Kelly, J.W. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135:17869-17880, 2013 Cited by PubMed: 24180271 DOI: 10.1021/ja408230k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation