4HJT

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide

Summary for 4HJT

Entry DOI	10.2210/pdb4hjt/pdb
Related	3CN0 3CN1 3HJO 3IMR 3IMT 4HJS 4HJU
Descriptor	Transthyretin, N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide (3 entities in total)
Functional Keywords	hormone binding protein, thyroxine, retinol binding protein, hormone binding protein-inhibitor complex, hormone binding protein/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28145.47
Authors	Connelly, S.,Wilson, I.A. (deposition date: 2012-10-14, release date: 2013-12-04, Last modification date: 2023-09-20)
Primary citation	Suh, E.H.,Liu, Y.,Connelly, S.,Genereux, J.C.,Wilson, I.A.,Kelly, J.W. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135:17869-17880, 2013 Cited by PubMed: 24180271 DOI: 10.1021/ja408230k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation