6HNR
Trypanosoma brucei PTR1 in complex with the triazine inhibitor 1 (F217)
Summary for 6HNR
| Entry DOI | 10.2210/pdb6hnr/pdb |
| Related | 6HNC |
| Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-(3,4-dichlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine, ... (7 entities in total) |
| Functional Keywords | trypanosoma brucei, pteridine reductase, ptr1, tbptr1, triazine inhibitors, oxidoreductase |
| Biological source | Trypanosoma brucei brucei More |
| Total number of polymer chains | 4 |
| Total formula weight | 127039.60 |
| Authors | Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2018-09-17, release date: 2019-05-08, Last modification date: 2024-01-24) |
| Primary citation | Landi, G.,Linciano, P.,Borsari, C.,Bertolacini, C.P.,Moraes, C.B.,Cordeiro-da-Silva, A.,Gul, S.,Witt, G.,Kuzikov, M.,Costi, M.P.,Pozzi, C.,Mangani, S. Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5:1105-1114, 2019 Cited by PubMed: 31012301DOI: 10.1021/acsinfecdis.8b00358 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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