6JWI
| Yeast Npl4 in complex with Lys48-linked diubiquitin | Descriptor: | BICINE, Nuclear protein localization protein 4, Ubiqutin, ... | Authors: | Sato, Y, Fukai, S. | Deposit date: | 2019-04-20 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat Commun, 10, 2019
|
|
8P0F
| Crystal structure of the VCB complex with compound 1. | Descriptor: | (3~{R},5~{R})-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-5-oxidanyl-2-oxidanylidene-1-pyridin-2-yl-piperidine-3-carboxamide, CHLORIDE ION, Elongin-B, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2023-05-10 | Release date: | 2023-05-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders Chemrxiv, 2023
|
|
6HEK
| Structure of human USP28 bound to Ubiquitin-PA | Descriptor: | CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ... | Authors: | Gersch, M, Komander, D. | Deposit date: | 2018-08-20 | Release date: | 2019-03-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
|
|
6HEI
| |
2G3Q
| |
2G45
| Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin | Descriptor: | CHLORIDE ION, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 5, ... | Authors: | Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D. | Deposit date: | 2006-02-21 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin. Cell(Cambridge,Mass.), 124, 2006
|
|
8IJ1
| Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
|
|
6KBE
| Structure of Deubiquitinase | Descriptor: | Polyubiquitin-C, Ubiquitin thioesterase | Authors: | Lu, L.N, Liu, L, Wang, F. | Deposit date: | 2019-06-24 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.339 Å) | Cite: | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
|
|
6K9P
| Structure of Deubiquitinase | Descriptor: | Ubiquitin, Ubiquitin thioesterase | Authors: | Lu, L.N, Liu, L, Wang, F. | Deposit date: | 2019-06-17 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
|
|
8IK6
| pUbl depleted Parkin complex with pUbiquitin | Descriptor: | E3 ubiquitin-protein ligase parkin, SULFATE ION, Ubiquitin, ... | Authors: | Lenka, D.R, Kumar, A. | Deposit date: | 2023-02-28 | Release date: | 2024-09-11 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans. Elife, 13, 2024
|
|
8IKM
| Trans complex of phospho parkin | Descriptor: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | Authors: | Lenka, D.R, Kumar, A. | Deposit date: | 2023-02-28 | Release date: | 2024-09-11 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans. Elife, 13, 2024
|
|
8IKV
| |
8IKT
| Ternary trans-complex of phospho-parkin with cis ACT and pUb | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-AMINOPROPANE, E3 ubiquitin-protein ligase parkin, ... | Authors: | Lenka, D.R, Kumar, A. | Deposit date: | 2023-03-01 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans. Elife, 13, 2024
|
|
6HR2
| Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | Authors: | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | Deposit date: | 2018-09-26 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15, 2019
|
|
6I7Q
| |
2HD5
| USP2 in complex with ubiquitin | Descriptor: | Polyubiquitin, Ubiquitin carboxyl-terminal hydrolase 2, ZINC ION | Authors: | Renatus, M, Kroemer, M. | Deposit date: | 2006-06-20 | Release date: | 2006-08-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2. Structure, 14, 2006
|
|
6HUE
| ParkinS65N | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | Authors: | McWilliams, T.G, Barini, E, Pohjolan-Pirhonen, R, Brooks, S.P, Singh, F, Burel, S, Balk, K, Kumar, A, Montava-Garriga, L, Prescott, A.R, Hassoun, S.M, Mouton-Liger, F, Ball, G, Hills, R, Knebel, A, Ulusoy, A, Di Monte, D.A, Tamjar, J, Antico, O, Fears, K, Smith, L, Brambilla, R, Palin, E, Valori, M, Eerola-Rautio, J, Tienari, P, Corti, O, Dunnett, S.B, Ganley, I.G, Suomalainen, A, Muqit, M.M.K. | Deposit date: | 2018-10-07 | Release date: | 2018-10-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Phosphorylation of Parkin at serine 65 is essential for its activation in vivo . Open Biology, 8, 2018
|
|
2K8C
| Solution structure of PLAA family ubiquitin binding domain (PFUC) trans isomer in complex with ubiquitin | Descriptor: | Phospholipase A-2-activating protein, Ubiquitin | Authors: | Fu, Q.S, Zhou, C.J, Gao, H.C, Lin, D.H, Hu, H.Y. | Deposit date: | 2008-09-04 | Release date: | 2009-05-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A2-activating Protein. J.Biol.Chem., 284, 2009
|
|
2K6D
| CIN85 Sh3-C domain in complex with ubiquitin | Descriptor: | SH3 domain-containing kinase-binding protein 1, Ubiquitin | Authors: | Forman-Kay, J, Bezsonova, I. | Deposit date: | 2008-07-07 | Release date: | 2008-08-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry, 47, 2008
|
|
6HIW
| Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the complete small mitoribosomal subunit in complex with mt-IF-3 | Descriptor: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ramrath, D, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2018-08-31 | Release date: | 2018-09-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes. Science, 362, 2018
|
|
2KTF
| |
2KDF
| NMR structure of minor S5a (196-306):K48 linked diubiquitin species | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin | Authors: | Zhang, N, Wang, Q, Ehlinger, A, Randles, L, Lary, J.W, Kang, Y, Haririnia, A, Cole, J.L, Fushman, D, Walters, K.J. | Deposit date: | 2009-01-06 | Release date: | 2009-09-01 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol.Cell, 35, 2009
|
|
2IBI
| Covalent Ubiquitin-USP2 Complex | Descriptor: | ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 2, ... | Authors: | Walker, J.R, Avvakumov, G.V, Bernstein, G, Xue, S, Finerty Jr, P.J, MacKenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-09-11 | Release date: | 2006-10-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Covalent Ubiquitin-USP2 Complex To be Published
|
|
2K8B
| Solution structure of PLAA family ubiquitin binding domain (PFUC) cis isomer in complex with ubiquitin | Descriptor: | Phospholipase A-2-activating protein, Ubiquitin | Authors: | Fu, Q.S, Zhou, C.J, Gao, H.C, Lin, D.H, Hu, H.Y. | Deposit date: | 2008-09-04 | Release date: | 2009-05-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A2-activating Protein. J.Biol.Chem., 284, 2009
|
|
2KDE
| NMR structure of major S5a (196-306):K48 linked diubiquitin species | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin | Authors: | Zhang, N, Wang, Q, Ehlinger, A, Randles, L, Lary, J.W, Kang, Y, Haririnia, A, Cole, J.L, Fushman, D, Walters, K.J. | Deposit date: | 2009-01-06 | Release date: | 2009-09-01 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol.Cell, 35, 2009
|
|