8P0F

Crystal structure of the VCB complex with compound 1.

Summary for 8P0F

• Entry DOI: 10.2210/pdb8p0f/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-C, Elongin-B, ... (6 entities in total)
• Functional Keywords: inhibitor, ligand, protac, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 83731.08

Authors

Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2023-05-10, release date: 2023-05-31, Last modification date: 2023-12-20)

• Primary citation: Scott, T.,Smethurst, C.,Westermaier, Y.,Mayer, M.,Greb, P.,Kousek, R.,Biberger, T.,Bader, G.,Jandova, Z.,Schmalhorst, P.,Fuchs, J.,Magarkar, A.,Hoenke, C.,Gerstberger, T.,Combs, S.,Pape, R.,Phul, S.,Kothiwale, S.,Bergner, A.,Moretti, R.; Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-lczzd

Experimental method

X-RAY DIFFRACTION (1.98 Å)