5XFQ
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![BU of 5xfq by Molmil](/molmil-images/mine/5xfq) | Ternary complex of PHF1, a DNA duplex and a histone peptide | Descriptor: | DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), PHD finger protein 1, Peptide from Histone H3, ... | Authors: | Wang, Z, Li, H. | Deposit date: | 2017-04-11 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Polycomb-like proteins link the PRC2 complex to CpG islands Nature, 549, 2017
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5XFO
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![BU of 5xfo by Molmil](/molmil-images/mine/5xfo) | Structure of the N-terminal domains of PHF1 | Descriptor: | PHD finger protein 1, ZINC ION | Authors: | Wang, Z, Li, H. | Deposit date: | 2017-04-11 | Release date: | 2017-09-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Polycomb-like proteins link the PRC2 complex to CpG islands Nature, 549, 2017
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5XFR
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![BU of 5xfr by Molmil](/molmil-images/mine/5xfr) | Ternary complex of MTF2, DNA and histone | Descriptor: | DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), Metal-response element-binding transcription factor 2, Peptide from Histone H3.1, ... | Authors: | Wang, Z, Li, H. | Deposit date: | 2017-04-11 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Polycomb-like proteins link the PRC2 complex to CpG islands Nature, 549, 2017
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5VMP
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![BU of 5vmp by Molmil](/molmil-images/mine/5vmp) | Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714 | Descriptor: | 3-({[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... | Authors: | Hosfield, D.J. | Deposit date: | 2017-04-28 | Release date: | 2017-09-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett, 8, 2017
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5VGI
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![BU of 5vgi by Molmil](/molmil-images/mine/5vgi) | Crystal Structure of KDM4 with the Small Molecule Inhibitor QC6352 | Descriptor: | 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... | Authors: | Hosfield, D.J. | Deposit date: | 2017-04-11 | Release date: | 2017-09-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett, 8, 2017
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6IIR
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![BU of 6iir by Molmil](/molmil-images/mine/6iir) | |
6IIQ
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![BU of 6iiq by Molmil](/molmil-images/mine/6iiq) | Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA | Descriptor: | 16-bp TA-rich DNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Hepatoma-derived growth factor-related protein 3, ... | Authors: | Wang, Z, Tian, W. | Deposit date: | 2018-10-07 | Release date: | 2019-04-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA Nucleic Acids Res., 2019
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6IIS
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![BU of 6iis by Molmil](/molmil-images/mine/6iis) | |
6IIT
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![BU of 6iit by Molmil](/molmil-images/mine/6iit) | |
6IIP
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![BU of 6iip by Molmil](/molmil-images/mine/6iip) | Apo-form structure of the HRP3 PWWP domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatoma-derived growth factor-related protein 3, SULFATE ION | Authors: | Wang, Z, Tian, W. | Deposit date: | 2018-10-07 | Release date: | 2019-04-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (0.951 Å) | Cite: | Apo-form structure of the HRP3 PWWP domain Nucleic Acids Res., 2019
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6J0D
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![BU of 6j0d by Molmil](/molmil-images/mine/6j0d) | Crystal structure of OsSUF4 | Descriptor: | ZINC ION, transcription factor | Authors: | Wang, B, Luo, Q. | Deposit date: | 2018-12-24 | Release date: | 2019-11-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment. Nat Commun, 10, 2019
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6S01
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![BU of 6s01 by Molmil](/molmil-images/mine/6s01) | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | Authors: | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | Deposit date: | 2019-06-13 | Release date: | 2019-12-18 | Last modified: | 2020-01-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nat.Struct.Mol.Biol., 27, 2020
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6WAT
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![BU of 6wat by Molmil](/molmil-images/mine/6wat) | complex structure of PHF1 | Descriptor: | Histone H3.1t peptide, PHD finger protein 1, UNKNOWN ATOM OR ION | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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6WAU
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![BU of 6wau by Molmil](/molmil-images/mine/6wau) | Complex structure of PHF19 | Descriptor: | Histone H3.1t peptide, PHD finger protein 19, UNKNOWN ATOM OR ION | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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6WAV
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![BU of 6wav by Molmil](/molmil-images/mine/6wav) | Crystal structure of PHF1 in complex with H3K36me3 substitution | Descriptor: | Histone H3.1, PHD finger protein 1, SULFATE ION, ... | Authors: | Dong, C, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Structural Genomics Consortium (SGC) | Deposit date: | 2020-03-26 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife, 9, 2020
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7AT8
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![BU of 7at8 by Molmil](/molmil-images/mine/7at8) | Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | Authors: | Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J. | Deposit date: | 2020-10-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3. Elife, 9, 2020
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6WKR
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![BU of 6wkr by Molmil](/molmil-images/mine/6wkr) | PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | Descriptor: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | Deposit date: | 2020-04-16 | Release date: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
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7LH9
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![BU of 7lh9 by Molmil](/molmil-images/mine/7lh9) | Crystal structure of BRPF2 PWWP domain in complex with DNA | Descriptor: | Bromodomain-containing protein 1, DNA | Authors: | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-01-21 | Release date: | 2021-02-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Biochim Biophys Acta Gene Regul Mech, 1864, 2021
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7EA8
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![BU of 7ea8 by Molmil](/molmil-images/mine/7ea8) | |
7EA5
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![BU of 7ea5 by Molmil](/molmil-images/mine/7ea5) | |
6ZV0
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![BU of 6zv0 by Molmil](/molmil-images/mine/6zv0) | TFIIS N-terminal domain (TND) from human LEDGF/p75 | Descriptor: | PC4 and SFRS1-interacting protein | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZV4
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![BU of 6zv4 by Molmil](/molmil-images/mine/6zv4) | Human TFIIS N-terminal domain in complex with IWS1 | Descriptor: | Transcription elongation factor A protein 1,Protein IWS1 homolog | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZV3
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![BU of 6zv3 by Molmil](/molmil-images/mine/6zv3) | TFIIS N-terminal domain (TND) from human MED26 | Descriptor: | Mediator of RNA polymerase II transcription subunit 26 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZV1
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![BU of 6zv1 by Molmil](/molmil-images/mine/6zv1) | TFIIS N-terminal domain (TND) from human IWS1 | Descriptor: | Protein IWS1 homolog | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZUY
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![BU of 6zuy by Molmil](/molmil-images/mine/6zuy) | Human TFIIS N-terminal domain (TND) | Descriptor: | Transcription elongation factor A protein 1 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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