5VMP
Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714
Summary for 5VMP
Entry DOI | 10.2210/pdb5vmp/pdb |
Descriptor | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | kdm4, inhibitor-complex, demethylase, epigenetics, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O75164 |
Total number of polymer chains | 4 |
Total formula weight | 173648.94 |
Authors | Hosfield, D.J. (deposition date: 2017-04-28, release date: 2017-09-27, Last modification date: 2023-10-04) |
Primary citation | Chen, Y.K.,Bonaldi, T.,Cuomo, A.,Del Rosario, J.R.,Hosfield, D.J.,Kanouni, T.,Kao, S.C.,Lai, C.,Lobo, N.A.,Matuszkiewicz, J.,McGeehan, A.,O'Connell, S.M.,Shi, L.,Stafford, J.A.,Stansfield, R.K.,Veal, J.M.,Weiss, M.S.,Yuen, N.Y.,Wallace, M.B. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett, 8:869-874, 2017 Cited by PubMed: 28835804DOI: 10.1021/acsmedchemlett.7b00220 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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