6J0D

Crystal structure of OsSUF4

Summary for 6J0D

• Entry DOI: 10.2210/pdb6j0d/pdb
• Descriptor: transcription factor, ZINC ION (3 entities in total)
• Functional Keywords: transcription factor, transcription
• Biological source: Oryza sativa subsp. japonica (Rice)
• Total number of polymer chains: 1
• Total formula weight: 11302.39

Authors

Wang, B.,Luo, Q. (deposition date: 2018-12-24, release date: 2019-11-06, Last modification date: 2024-11-13)

Primary citation

Liu, B.,Liu, Y.,Wang, B.,Luo, Q.,Shi, J.,Gan, J.,Shen, W.H.,Yu, Y.,Dong, A.
The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment.
Nat Commun, 10:2999-2999, 2019

PubMed Abstract: The different genome-wide distributions of tri-methylation at H3K36 (H3K36me3) in various species suggest diverse mechanisms for H3K36me3 establishment during evolution. Here, we show that the transcription factor OsSUF4 recognizes a specific 7-bp DNA element, broadly distributes throughout the rice genome, and recruits the H3K36 methyltransferase SDG725 to target a set of genes including the key florigen genes RFT1 and Hd3a to promote flowering in rice. Biochemical and structural analyses indicate that several positive residues within the zinc finger domain are vital for OsSUF4 function in planta. Our results reveal a regulatory mechanism contributing to H3K36me3 distribution in plants.

PubMed: 31278262
DOI: 10.1038/s41467-019-10850-5

Experimental method

X-RAY DIFFRACTION (1.9 Å)