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4O17
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BU of 4o17 by Molmil
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Descriptor: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O28
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BU of 4o28 by Molmil
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Descriptor: 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-17
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
6VVT
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BU of 6vvt by Molmil
Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and antibiotic Sorangicin
Descriptor: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2020-02-18
Release date:2020-10-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Proc.Natl.Acad.Sci.USA, 117, 2020
4O1B
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BU of 4o1b by Molmil
The crystal structure of a mutant NAMPT (G217R) in complex with an inhibitor APO866
Descriptor: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ...
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1A
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BU of 4o1a by Molmil
The crystal structure of the mutant NAMPT G217R
Descriptor: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1D
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BU of 4o1d by Molmil
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Descriptor: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ...
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
6VVV
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BU of 6vvv by Molmil
Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase
Descriptor: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2020-02-18
Release date:2020-10-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Proc.Natl.Acad.Sci.USA, 117, 2020
4O15
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BU of 4o15 by Molmil
The crystal structure of a mutant NAMPT (S165F) in complex with GNE-618
Descriptor: 1,2-ETHANEDIOL, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1C
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BU of 4o1c by Molmil
The crystal structures of a mutant NAMPT H191R
Descriptor: 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
Authors:Oh, A, Coons, M, Brillantes, B, Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
1QHY
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BU of 1qhy by Molmil
CHLORAMPHENICOL PHOSPHOTRANSFERASE FROM STREPTOMYCES VENEZUELAE IN COMPLEX WITH ATPGAMMAS AND CHLORAMPHENICOL
Descriptor: CHLORAMPHENICOL, CHLORAMPHENICOL PHOSPHOTRANSFERASE, MAGNESIUM ION, ...
Authors:Izard, T.
Deposit date:1999-06-01
Release date:2000-06-07
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structures of Chloramphenicol Phosphotransferase Reveal a Novel Inactivation Mechanism
Embo J., 19, 2000
4EAI
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BU of 4eai by Molmil
Co-crystal structure of an AMPK core with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAL
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BU of 4eal by Molmil
Co-crystal of AMPK core with ATP soaked with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAJ
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BU of 4eaj by Molmil
Co-crystal of AMPK core with AMP soaked with ATP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
6C9G
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BU of 6c9g by Molmil
AMP-activated protein kinase bound to pharmacological activator R739
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9F
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BU of 6c9f by Molmil
AMP-activated protein kinase bound to pharmacological activator R734
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9J
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BU of 6c9j by Molmil
AMP-activated protein kinase bound to pharmacological activator R734
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Brunzelle, J.S, Hitoshi, Y, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
5OE6
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BU of 5oe6 by Molmil
Crystal structure of the N-terminal domain of PqsA in complex with 6-fluoroanthraniloyl-AMP (crystal form 1)
Descriptor: 6-fluoroanthraniloyl-AMP, Anthranilate--CoA ligase, TRIETHYLENE GLYCOL
Authors:Witzgall, F, Ewert, W, Blankenfeldt, W.
Deposit date:2017-07-07
Release date:2017-09-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis.
Chembiochem, 18, 2017
8UNH
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BU of 8unh by Molmil
Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Sliding clamp, ...
Authors:Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J.
Deposit date:2023-10-19
Release date:2023-12-13
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
8UNF
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BU of 8unf by Molmil
Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp and DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Sliding clamp, ...
Authors:Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J.
Deposit date:2023-10-18
Release date:2023-12-13
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
4CLA
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BU of 4cla by Molmil
ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE
Descriptor: CHLORAMPHENICOL, COBALT (II) ION, TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE
Authors:Leslie, A.G.W.
Deposit date:1990-10-23
Release date:1992-01-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase.
Biochemistry, 30, 1991
8UH7
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BU of 8uh7 by Molmil
Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Primer DNA strand, ...
Authors:Gee, C.L, Marcus, K, Kelch, B.A, Makino, D.L.
Deposit date:2023-10-07
Release date:2023-12-13
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.628 Å)
Cite:Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
8UK9
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BU of 8uk9 by Molmil
Structure of T4 Bacteriophage clamp loader mutant D110C bound to the T4 clamp, primer-template DNA, and ATP analog
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, DNA primer, ...
Authors:Marcus, K, Ghaffari-Kashani, S, Gee, C.L.
Deposit date:2023-10-12
Release date:2023-12-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
Nat.Struct.Mol.Biol., 31, 2024
5HV1
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BU of 5hv1 by Molmil
Rifampin phosphotransferase in complex with AMPPNP and rifampin from Listeria monocytogenes
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphoenolpyruvate synthase, ...
Authors:Zhang, P, Qi, X.
Deposit date:2016-01-28
Release date:2016-03-30
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:Structural basis of rifampin inactivation by rifampin phosphotransferase
Proc.Natl.Acad.Sci.USA, 113, 2016
2JKJ
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BU of 2jkj by Molmil
DraE Adhesin in complex with Chloramphenicol Succinate
Descriptor: CHLORAMPHENICOL, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, SULFATE ION, ...
Authors:Pettigrew, D.M, Roversi, P, Davies, S.G, Russell, A.J, Lea, S.M.
Deposit date:2008-08-28
Release date:2008-12-16
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Structural Study of the Interaction between the Dr Haemagglutinin Drae and Derivatives of Chloramphenicol
Acta Crystallogr.,Sect.D, 65, 2009
8GJK
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BU of 8gjk by Molmil
Multi-drug efflux pump RE-CmeB bound with ampicillin
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter
Authors:Zhang, Z.
Deposit date:2023-03-16
Release date:2023-05-31
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023

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