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3TIO
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BU of 3tio by Molmil
Crystal structures of yrdA from Escherichia coli, a homologous protein of gamma-class carbonic anhydrase, show possible allosteric conformations
Descriptor: PHOSPHATE ION, Protein YrdA, ZINC ION
Authors:Park, H.M, Choi, J.W, Lee, J.E, Jung, C.H, Kim, B.Y, Kim, J.S.
Deposit date:2011-08-21
Release date:2012-08-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structures of the gamma-class carbonic anhydrase homologue YrdA suggest a possible allosteric switch
Acta Crystallogr.,Sect.D, 68, 2012
3TIS
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BU of 3tis by Molmil
Crystal structures of yrdA from Escherichia coli, a homologous protein of gamma-class carbonic anhydrases, show possible allosteric conformations
Descriptor: Protein YrdA, ZINC ION
Authors:Park, H.M, Chio, J.W, Lee, J.E, Jung, J.H, Kim, B.Y, Kim, J.S.
Deposit date:2011-08-21
Release date:2012-08-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the gamma-class carbonic anhydrase homologue YrdA suggest a possible allosteric switch
Acta Crystallogr.,Sect.D, 68, 2012
5Y88
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BU of 5y88 by Molmil
Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat, ...
Authors:Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y.
Deposit date:2017-08-20
Release date:2018-08-01
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae
Cell(Cambridge,Mass.), 171, 2017
5YLH
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BU of 5ylh by Molmil
Structure of GH113 beta-1,4-mannanase
Descriptor: beta-1,4-mannanase
Authors:Jiang, Z.Q, You, X, Yang, S.Q, Huang, P, Ma, J.W.
Deposit date:2017-10-17
Release date:2018-06-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase from Amphibacillus xylanus
J. Biol. Chem., 293, 2018
5YLK
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BU of 5ylk by Molmil
Complex structure of GH 113 family beta-1,4-mannanase with mannobiose
Descriptor: beta-1,4-mannanase, beta-D-mannopyranose, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose
Authors:Jiang, Z.Q, You, X, Yang, S.Q, Huang, P, Ma, J.W.
Deposit date:2017-10-17
Release date:2018-06-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase fromn Amphibacillus xylanus
J. Biol. Chem., 293, 2018
6TH6
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BU of 6th6 by Molmil
Cryo-EM Structure of T. kodakarensis 70S ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M.
Deposit date:2019-11-18
Release date:2020-07-29
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
6T9I
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BU of 6t9i by Molmil
cryo-EM structure of transcription coactivator SAGA
Descriptor: Protein SPT3, SAGA-associated factor 73, Transcription factor SPT20, ...
Authors:Wang, H, Cheung, A, Cramer, P.
Deposit date:2019-10-28
Release date:2020-01-29
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the transcription coactivator SAGA.
Nature, 577, 2020
6TBL
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BU of 6tbl by Molmil
Crystal structure of MMS19(CTD)-CIAO1-CIAO2B CIA targeting complex
Descriptor: 1,2-ETHANEDIOL, MIP18 family protein galla-2, MMS19 nucleotide excision repair protein homolog, ...
Authors:Kassube, S.A, Thoma, N.H.
Deposit date:2019-11-01
Release date:2020-07-29
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Nat.Struct.Mol.Biol., 27, 2020
6TBN
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BU of 6tbn by Molmil
Crystal structure of CIAO1-CIAO2B CIA core complex
Descriptor: MIP18 family protein galla-2, Probable cytosolic iron-sulfur protein assembly protein Ciao1, SODIUM ION
Authors:Kassube, S.A, Thoma, N.H.
Deposit date:2019-11-01
Release date:2020-07-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Nat.Struct.Mol.Biol., 27, 2020
6TC0
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BU of 6tc0 by Molmil
Crystal structure of MMS19-CIAO1-CIAO2B CIA targeting complex
Descriptor: MIP18 family protein galla-2, MMS19 nucleotide excision repair protein homolog, Probable cytosolic iron-sulfur protein assembly protein Ciao1
Authors:Kassube, S.A, Thoma, N.H.
Deposit date:2019-11-04
Release date:2020-07-29
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Nat.Struct.Mol.Biol., 27, 2020
6TB3
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BU of 6tb3 by Molmil
yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex
Descriptor: 25S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R.
Deposit date:2019-10-31
Release date:2020-04-22
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
6TTU
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BU of 6ttu by Molmil
Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2
Descriptor: CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Prabu, J.R, Schulman, B.A.
Deposit date:2019-12-30
Release date:2020-02-12
Last modified:2020-03-04
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Nature, 578, 2020
5Z58
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BU of 5z58 by Molmil
Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y.
Deposit date:2018-01-17
Release date:2018-09-19
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
6U80
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BU of 6u80 by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Descriptor: 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5
Authors:Zhao, B, Wang, F.
Deposit date:2019-09-04
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
3SN6
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BU of 3sn6 by Molmil
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
3SHF
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BU of 3shf by Molmil
Crystal structure of the R265S mutant of full-length murine Apaf-1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Apoptotic peptidase activating factor 1, GAMMA-BUTYROLACTONE
Authors:Eschenburg, S, Reubold, T.F.
Deposit date:2011-06-16
Release date:2011-08-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Structure, 19, 2011
6U4Y
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BU of 6u4y by Molmil
Crystal Structure of an EZH2-EED Complex in an Oligomeric State
Descriptor: Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
Authors:Jiao, L, Liu, X.
Deposit date:2019-08-26
Release date:2020-07-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:A partially disordered region connects gene repression and activation functions of EZH2.
Proc.Natl.Acad.Sci.USA, 117, 2020
3SSA
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BU of 3ssa by Molmil
Crystal structure of subunit B mutant N157T of the A1AO ATP synthase
Descriptor: 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sundararaman, L, Manimekalai, M.S.S, Jeyakanthan, J, Gruber, G.
Deposit date:2011-07-08
Release date:2012-09-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of subunit A mutants H156A, N157A and N157T of the A1AO ATP synthase
To be Published
5ZWO
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BU of 5zwo by Molmil
Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom
Descriptor: 13 kDa ribonucleoprotein-associated protein, 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, ...
Authors:Bai, R, Wan, R, Yan, C, Shi, Y.
Deposit date:2018-05-16
Release date:2018-08-29
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
6U42
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BU of 6u42 by Molmil
Natively decorated ciliary doublet microtubule
Descriptor: DC1, DC2, DC3, ...
Authors:Ma, M, Stoyanova, M, Rademacher, G, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2019-08-22
Release date:2019-11-13
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the Decorated Ciliary Doublet Microtubule.
Cell, 179, 2019
6UFX
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BU of 6ufx by Molmil
WD repeat-containing protein 5 complexed with N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide (compound 13)
Descriptor: N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide, WD repeat-containing protein 5
Authors:Rietz, T.A, Fesik, S.W, Zhao, B.
Deposit date:2019-09-25
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.015 Å)
Cite:Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J.Med.Chem., 63, 2020
6UCS
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BU of 6ucs by Molmil
Discovery and Structure-Based optimization of potent and selective WDR5 inhibitors containing a dihydroisoquinolinone bicyclic core
Descriptor: 2-amino-3-{[(5P)-2-[(3,5-dimethoxyphenyl)methyl]-5-(4-fluoro-2-methylphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-1-methyl-1H-imidazol-3-ium, WD repeat-containing protein 5
Authors:Zhao, B.
Deposit date:2019-09-17
Release date:2020-01-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J.Med.Chem., 63, 2020
6UH5
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BU of 6uh5 by Molmil
Structural basis of COMPASS eCM recognition of the H2Bub nucleosome
Descriptor: Bre2, DNA (146-MER), H3 N-terminus, ...
Authors:Hsu, P.L, Shi, H, Zheng, N.
Deposit date:2019-09-26
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.
Mol.Cell, 76, 2019
6UIK
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BU of 6uik by Molmil
Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor: 5-bromo-3-chloro-N-(1-cyclopentyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domanin 5
Authors:Zhao, B.
Deposit date:2019-10-01
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
6UIF
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BU of 6uif by Molmil
Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor: 4-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-1-cyclopentyl-N-methyl-1H-imidazole-2-carboxamide, WD repeat domain 5
Authors:Zhao, B.
Deposit date:2019-09-30
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020

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