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6U80

Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction

Summary for 6U80
Entry DOI10.2210/pdb6u80/pdb
DescriptorWD repeat-containing protein 5, 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide (3 entities in total)
Functional Keywordswdr5, myc, rbbp5, structure-based design, high-throughput screening, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight69334.29
Authors
Zhao, B.,Wang, F. (deposition date: 2019-09-04, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citationMacdonald, J.D.,Chacon Simon, S.,Han, C.,Wang, F.,Shaw, J.G.,Howes, J.E.,Sai, J.,Yuh, J.P.,Camper, D.,Alicie, B.M.,Alvarado, J.,Nikhar, S.,Payne, W.,Aho, E.R.,Bauer, J.A.,Zhao, B.,Phan, J.,Thomas, L.R.,Rossanese, O.W.,Tansey, W.P.,Waterson, A.G.,Stauffer, S.R.,Fesik, S.W.
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62:11232-11259, 2019
Cited by
PubMed: 31724864
DOI: 10.1021/acs.jmedchem.9b01411
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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