8IBY
| Structure of R2 with 5'ORF | Descriptor: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8QZS
| Cryo-EM structure of the cross-exon B-like complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-29 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
7OEA
| Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core) [3END-CORE] | Descriptor: | 3' vRNA, MAGNESIUM ION, RNA-directed RNA polymerase L, ... | Authors: | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | Deposit date: | 2021-05-02 | Release date: | 2021-12-01 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
|
|
7OEB
| Lassa virus L protein bound to 3' promoter RNA (well-resolved endonuclease) [3END-ENDO] | Descriptor: | 3' vRNA, MAGNESIUM ION, RNA-directed RNA polymerase L, ... | Authors: | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | Deposit date: | 2021-05-02 | Release date: | 2021-12-01 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
|
|
8DVU
| |
4OL8
| Ty3 reverse transcriptase bound to DNA/RNA | Descriptor: | 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ... | Authors: | Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M. | Deposit date: | 2014-01-23 | Release date: | 2014-03-05 | Last modified: | 2014-04-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nat.Struct.Mol.Biol., 21, 2014
|
|
4PJ3
| Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | Descriptor: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | Deposit date: | 2014-05-11 | Release date: | 2015-01-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nat.Struct.Mol.Biol., 22, 2015
|
|
6D0L
| Structure of human TIRR | Descriptor: | Tudor-interacting repair regulator protein | Authors: | Cui, G, Botuyan, M.V, Mer, G. | Deposit date: | 2018-04-10 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018
|
|
3AYH
| |
6IID
| Human EXOG-H140A in complex with RNA-DNA chimeric duplex | Descriptor: | DNA (5'-D(*CP*GP*TP*GP*AP*CP*AP*TP*CP*CP*CP*G)-3'), DNA/RNA (5'-R(P*CP*GP*GP*GP*A)-D(P*T)-R(P*G)-D(P*T)-R(P*CP*AP*CP*G)-3'), MAGNESIUM ION, ... | Authors: | Wu, C.C, Lin, J.L.J, Yuan, H.S. | Deposit date: | 2018-10-04 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.986 Å) | Cite: | A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res., 47, 2019
|
|
6MCE
| |
6F9N
| CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Clerici, M, Jinek, M. | Deposit date: | 2017-12-14 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex. Elife, 6, 2017
|
|
7SXP
| |
7OJL
| Lassa virus L protein in a pre-initiation conformation [PREINITIATION] | Descriptor: | 3' RNA, 5' RNA, MANGANESE (II) ION, ... | Authors: | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | Deposit date: | 2021-05-16 | Release date: | 2021-12-01 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
|
|
5TBX
| hnRNP A18 RNA Recognition Motif | Descriptor: | ACETATE ION, Cold-inducible RNA-binding protein, NICKEL (II) ION | Authors: | Coburn, K.M, Melville, Z, Aligholizadeh, E, Roth, B.M, Varney, K.M, Weber, D.J. | Deposit date: | 2016-09-13 | Release date: | 2017-04-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.767 Å) | Cite: | Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif. Acta Crystallogr F Struct Biol Commun, 73, 2017
|
|
3P56
| |
6FUW
| Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | Authors: | Clerici, M, Faini, M, Jinek, M. | Deposit date: | 2018-02-28 | Release date: | 2018-03-21 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nat. Struct. Mol. Biol., 25, 2018
|
|
5WY0
| Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet | Descriptor: | S-ADENOSYLMETHIONINE, Small RNA 2'-O-methyltransferase | Authors: | Peng, L, Ma, J.B, Wu, L.G, Huang, Y. | Deposit date: | 2017-01-10 | Release date: | 2018-01-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain J. Biol. Chem., 293, 2018
|
|
3BK2
| Crystal Structure Analysis of the RNase J/UMP complex | Descriptor: | GLYCEROL, Metal dependent hydrolase, SULFATE ION, ... | Authors: | de la Sierra-Gallay, I.L, Zig, L, Putzer, H. | Deposit date: | 2007-12-05 | Release date: | 2008-01-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the dual activity of RNase J Nat.Struct.Mol.Biol., 15, 2008
|
|
7XD9
| Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Wu, J, Wang, X, Gong, P. | Deposit date: | 2022-03-26 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7XD8
| Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) | Descriptor: | GLYCEROL, NS5, RNA (30-mer), ... | Authors: | Wu, J, Wang, X, Gong, P. | Deposit date: | 2022-03-26 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4RY6
| C-terminal mutant (W550A) of HCV/J4 RNA polymerase | Descriptor: | HCV J4 RNA polymerase (NS5B) | Authors: | Jaeger, J, Cherry, A, Dennis, C. | Deposit date: | 2014-12-13 | Release date: | 2014-12-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
|
|
4RY4
| C-terminal mutant (Y448F) of HCV/J4 RNA polymerase | Descriptor: | HCV J4 RNA polymerase (NS5B) | Authors: | Jaeger, J, Cherry, A, Dennis, C. | Deposit date: | 2014-12-13 | Release date: | 2014-12-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
|
|
4RY7
| C-terminal mutant (D559E) of HCV/J4 RNA polymerase | Descriptor: | HCV J4 RNA polymerase (NS5B) | Authors: | Jaeger, J, Cherry, A, Dennis, C. | Deposit date: | 2014-12-13 | Release date: | 2014-12-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
|
|
4RY5
| C-terminal mutant (W550N) of HCV/J4 RNA polymerase | Descriptor: | HCV J4 RNA polymerase (NS5B), MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE | Authors: | Jaeger, J, Cherry, A, Dennis, C. | Deposit date: | 2014-12-13 | Release date: | 2014-12-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation. J.Virol., 89, 2015
|
|