4RY4

C-terminal mutant (Y448F) of HCV/J4 RNA polymerase

Summary for 4RY4

• Entry DOI: 10.2210/pdb4ry4/pdb
• Related: 1NB4 4RY5 4RY6 4RY7
• Descriptor: HCV J4 RNA polymerase (NS5B) (2 entities in total)
• Functional Keywords: hepatitis c virus, replication, function analysis, viral rna polymerase, rna rntp mg, nucleotide transfer, transferase
• Biological source: Hepatitis C virus isolate HC-J4 (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 2
• Total formula weight: 126881.48

Authors

Jaeger, J.,Cherry, A.,Dennis, C. (deposition date: 2014-12-13, release date: 2014-12-31, Last modification date: 2023-09-20)

• Primary citation: Cherry, A.L.,Dennis, C.A.,Baron, A.,Eisele, L.E.,Thommes, P.A.,Jaeger, J.; Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation.; J.Virol., 89:2052-2063, 2015; PubMed: 25428878; DOI: 10.1128/JVI.01106-14

Experimental method

X-RAY DIFFRACTION (2.59 Å)