6IID

Human EXOG-H140A in complex with RNA-DNA chimeric duplex

Summary for 6IID

• Entry DOI: 10.2210/pdb6iid/pdb
• Related: 5ZKI 5ZKJ
• Descriptor: Nuclease EXOG, mitochondrial, DNA/RNA (5'-R(P*CP*GP*GP*GP*A)-D(P*T)-R(P*G)-D(P*T)-R(P*CP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*GP*AP*CP*AP*TP*CP*CP*CP*G)-3'), ... (5 entities in total)
• Functional Keywords: enzyme-substrate complex, mitochondrial exonuclease, hydrolase-dna complex, dna binding protein, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 186397.40

Authors

Wu, C.C.,Lin, J.L.J.,Yuan, H.S. (deposition date: 2018-10-04, release date: 2019-04-03, Last modification date: 2023-11-22)

• Primary citation: Wu, C.C.,Lin, J.L.J.,Yang-Yen, H.F.,Yuan, H.S.; A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.; Nucleic Acids Res., 47:5405-5419, 2019; PubMed: 30949702; DOI: 10.1093/nar/gkz241

Experimental method

X-RAY DIFFRACTION (2.986 Å)