6ZUO
| Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | Deposit date: | 2020-07-23 | Release date: | 2021-05-12 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
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6ZV6
| Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | Deposit date: | 2020-07-24 | Release date: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
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6ZPN
| Crystal structure of Chaetomium thermophilum Raptor | Descriptor: | WD_REPEATS_REGION domain-containing protein | Authors: | Imseng, S, Boehm, R, Jakob, R.P, Hall, M.N, Hiller, S, Maier, T. | Deposit date: | 2020-07-08 | Release date: | 2021-05-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Mol.Cell, 81, 2021
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4ZOV
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4ZGK
| Structure of Mdm2 with low molecular weight inhibitor. | Descriptor: | (5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one, E3 ubiquitin-protein ligase Mdm2 | Authors: | Twarda-Clapa, A, Zak, K.M, Wrona, E.M, Grudnik, P, Dubin, G, Holak, T.A. | Deposit date: | 2015-04-23 | Release date: | 2016-10-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction. ACS Chem. Biol., 11, 2016
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8OZ0
| Structure of a human 48S translation initiation complex with eIF4F and eIF4A | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Fraser, C.S, Ramakrishnan, V. | Deposit date: | 2023-05-06 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat.Struct.Mol.Biol., 31, 2024
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4ZOX
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7N9F
| Structure of the in situ yeast NPC | Descriptor: | Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ... | Authors: | Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S. | Deposit date: | 2021-06-17 | Release date: | 2022-01-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (37 Å) | Cite: | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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5A1U
| The structure of the COPI coat triad | Descriptor: | ADP-RIBOSYLATION FACTOR 1, COATOMER SUBUNIT ALPHA, COATOMER SUBUNIT BETA, ... | Authors: | Dodonova, S.O, Diestelkoetter-Bachert, P, von Appen, A, Hagen, W.J.H, Beck, R, Beck, M, Wieland, F, Briggs, J.A.G. | Deposit date: | 2015-05-06 | Release date: | 2015-07-08 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (13 Å) | Cite: | Vesicular Transport. A Structure of the Copi Coat and the Role of Coat Proteins in Membrane Vesicle Assembly. Science, 349, 2015
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7AOA
| Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, Histone-binding protein RBBP4, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (19.4 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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7N9Y
| Full-length TcdB and CSPG4 (401-560) complex | Descriptor: | Chondroitin sulfate proteoglycan 4, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-18 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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3LYK
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3LYP
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5ANN
| Structure of fructofuranosidase from Xanthophyllomyces dendrorhous | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-FRUCTOFURANOSIDASE, ... | Authors: | Ramirez-Escudero, M, Sanz-Aparicio, J. | Deposit date: | 2015-09-07 | Release date: | 2016-02-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural Analysis of Beta-Fructofuranosidase from Xanthophyllomyces Dendrorhous Reveals Unique Features and the Crucial Role of N-Glycosylation in Oligomerization and Activity J.Biol.Chem., 291, 2016
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5AXH
| Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus, D312G mutant in complex with isomaltohexaose | Descriptor: | Dextranase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Suzuki, N, Kishine, N, Fujimoto, Z, Sakurai, M, Momma, M, Ko, J.A, Nam, S.H, Kimura, A, Kim, Y.M. | Deposit date: | 2015-07-29 | Release date: | 2015-11-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus J.Biochem., 159, 2016
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7APK
| Structure of the human THO - UAP56 complex | Descriptor: | Spliceosome RNA helicase DDX39B, THO complex subunit 1, THO complex subunit 2, ... | Authors: | Hohmann, U, Puehringer, T, Plaschka, C. | Deposit date: | 2020-10-17 | Release date: | 2020-12-16 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the human core transcription-export complex reveals a hub for multivalent interactions. Elife, 9, 2020
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7B7D
| Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | Authors: | Ranjan, N, Pochopien, A.A, Wu, C.C, Beckert, B, Blanchet, S, Green, R, Rodnina, M.V, Wilson, D.N. | Deposit date: | 2020-12-10 | Release date: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | eEF3 promotes late stages of tRNA translocation including E-tRNA release from the ribosome To Be Published
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8Q1N
| Cyclic peptide binder of the WBM-site of WDR5 | Descriptor: | Cyclic peptide inhibitor, WD repeat-containing protein 5 | Authors: | Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. | Deposit date: | 2023-08-01 | Release date: | 2023-09-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.843 Å) | Cite: | Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59, 2023
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7AY0
| Crystal structure of truncated USP1-UAF1 | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ZINC ION | Authors: | Arkinson, C, Rennie, M.L, Walden, H. | Deposit date: | 2020-11-10 | Release date: | 2021-03-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
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7AY2
| Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ... | Authors: | Arkinson, C, Rennie, M.L, Walden, H. | Deposit date: | 2020-11-10 | Release date: | 2021-03-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
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7AY1
| Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | Descriptor: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | Authors: | Rennie, M.L, Arkinson, C, Walden, H. | Deposit date: | 2020-11-10 | Release date: | 2021-03-24 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
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8PPL
| MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | Deposit date: | 2023-07-07 | Release date: | 2023-10-18 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses. Mol.Cell, 83, 2023
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8PPK
| Bat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunit | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | Deposit date: | 2023-07-07 | Release date: | 2023-10-18 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses. Mol.Cell, 83, 2023
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7ASE
| 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase | Descriptor: | 18S, 40S ribosomal protein S10, putative, ... | Authors: | Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y. | Deposit date: | 2020-10-27 | Release date: | 2021-04-14 | Last modified: | 2021-04-21 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts. Cell Rep, 33, 2020
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7PQH
| Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains). | Descriptor: | Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8 | Authors: | Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R. | Deposit date: | 2021-09-17 | Release date: | 2023-01-18 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat.Struct.Mol.Biol., 30, 2023
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