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4KV5
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BU of 4kv5 by Molmil
scFv GC1009 in complex with TGF-beta1.
Descriptor: Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein
Authors:Wei, R, Moulin, A.G, Mathieu, M.
Deposit date:2013-05-22
Release date:2014-09-24
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
7C53
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BU of 7c53 by Molmil
Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1
Descriptor: CALCIUM ION, Spike protein S2',pan-CoVs inhibitor EK1
Authors:Zhu, Y, Yang, X, Sun, F.
Deposit date:2020-05-19
Release date:2021-05-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.278 Å)
Cite:Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation.
Signal Transduct Target Ther, 6, 2021
7UP2
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BU of 7up2 by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP1
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BU of 7up1 by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP3
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BU of 7up3 by Molmil
NDM1-inhibitor co-structure
Descriptor: (3P)-4-[4-(hydroxymethyl)phenyl]-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOX
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BU of 7uox by Molmil
NDM1-inhibitor co-structure
Descriptor: (2M)-4'-(hydroxymethyl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-ol, ACETATE ION, CADMIUM ION, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOY
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BU of 7uoy by Molmil
NDM1-inhibitor co-structure
Descriptor: (6P)-4-amino-6-(2H-tetrazol-5-yl)benzene-1,3-disulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
Authors:Scapin, G, Fischmann, T.O.
Deposit date:2022-04-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UYD
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BU of 7uyd by Molmil
Inhibitor bound VIM1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ...
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYC
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BU of 7uyc by Molmil
Inhibitor bound VIM1
Descriptor: (2P)-4'-(piperidin-4-yl)-4-[(piperidin-4-yl)methyl]-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, MAGNESIUM ION, ...
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYA
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BU of 7uya by Molmil
Inhibitor bound VIM1
Descriptor: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
7UYB
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BU of 7uyb by Molmil
Inhibitor bound VIM1
Descriptor: (2M)-4'-(piperidin-4-yl)-2-(1H-tetrazol-5-yl)-4-(trifluoromethyl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
Authors:Fischmann, T.O, Scapin, G.
Deposit date:2022-05-06
Release date:2023-05-24
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Structure Guided Discovery of Novel Pan Metallo-beta-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J.Med.Chem., 67, 2024
1MZJ
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BU of 1mzj by Molmil
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
Descriptor: ACETYL GROUP, Beta-ketoacylsynthase III, COENZYME A
Authors:Pan, H, Tsai, S.C, Meadows, E.S, Miercke, L.J.W, Keatinge-Clay, A, O'Connell, J, Khosla, C, Stroud, R.M.
Deposit date:2002-10-08
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
6WCE
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BU of 6wce by Molmil
Structure of the periplasmic binding protein P5PA
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Pyridoxal-5-phosphate binding protein A (P5PA)
Authors:Pan, C, Zimmer, A, Shah, M, Huynh, M, Lai, C.C.L, Sit, B, Hooda, Y, Moraes, T.F.
Deposit date:2020-03-30
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Actinobacillus utilizes a binding protein-dependent ABC transporter to acquire the active form of vitamin B 6 .
J.Biol.Chem., 297, 2021
1GHT
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BU of 1ght by Molmil
SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF GAMMA DELTA RESOLVASE
Descriptor: TRANSPOSON GAMMA-DELTA RESOLVASE
Authors:Pan, B, Mullen, G.P.
Deposit date:2001-01-11
Release date:2001-08-01
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the catalytic domain of gammadelta resolvase. Implications for the mechanism of catalysis.
J.Mol.Biol., 310, 2001
6DZN
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BU of 6dzn by Molmil
Pan-ebolavirus human antibody ADI-15878 Fab
Descriptor: 2-(2-ETHOXYETHOXY)ETHANOL, Antibody ADI-15878, heavy chain, ...
Authors:Murin, C.D, Ward, A.B, Bruhn, J.F, Stanfield, R.
Deposit date:2018-07-05
Release date:2018-09-12
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.
Cell Rep, 24, 2018
2G77
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BU of 2g77 by Molmil
Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3
Descriptor: ALUMINUM FLUORIDE, GTPase-activating protein GYP1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Pan, X, Eathiraj, S, Munson, M, Lambright, D.G.
Deposit date:2006-02-27
Release date:2006-07-25
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Nature, 442, 2006
4F8H
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BU of 4f8h by Molmil
X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel
Descriptor: (R)-ketamine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Proton-gated ion channel, ...
Authors:Pan, J.J, Chen, Q, Willenbring, D, Kong, X.P, Cohen, A, Xu, Y, Tang, P.
Deposit date:2012-05-17
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine.
Structure, 20, 2012
1FX9
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BU of 1fx9 by Molmil
CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + SULPHATE IONS)
Descriptor: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHOLIPASE A2, ...
Authors:Pan, Y.H, Epstein, T.M, Jain, M.K, Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
1FXF
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BU of 1fxf by Molmil
CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + PHOSPHATE IONS)
Descriptor: 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHATE ION, ...
Authors:Pan, Y.H, Epstein, T.M, Jain, M.K, Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
1CK0
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BU of 1ck0 by Molmil
ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM
Descriptor: PROTEIN (IGG1-KAPPA ANTIBODY 131 (HEAVY CHAIN)), PROTEIN (IGG1-KAPPA ANTIBODY 131 (LIGHT CHAIN))
Authors:Pan, Y.H, Amzel, L.M.
Deposit date:1999-04-26
Release date:2003-08-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Angiotensin II and a Phage-Display Selected Cyclic Peptide in Complex with Fab131: Making Angiotensin II Analogs
To be Published
1D0Q
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BU of 1d0q by Molmil
STRUCTURE OF THE ZINC-BINDING DOMAIN OF BACILLUS STEAROTHERMOPHILUS DNA PRIMASE
Descriptor: DNA PRIMASE, ZINC ION
Authors:Pan, H, Wigley, D.B.
Deposit date:1999-09-14
Release date:2000-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase.
Structure Fold.Des., 8, 2000
1DUI
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BU of 1dui by Molmil
Subtilisin BPN' from Bacillus amyloliquefaciens, crystal growth mutant
Descriptor: DIISOPROPYL PHOSPHONATE, PROTEIN (SUBTILISIN BPN'), SODIUM ION
Authors:Pan, Q, Gallagher, D.T.
Deposit date:2000-01-17
Release date:2000-01-28
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing Protein Interaction Chemistry Through Crystal Growth: Structure, Mutation, and Mechanism in Subtilisin s88
J.Cryst.Growth, 212, 2000
5JBV
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BU of 5jbv by Molmil
Lys27-linked triubiquitin
Descriptor: D-ubiquitin, NITRATE ION, Ubiquitin
Authors:Pan, M, Gao, S, Zheng, Y.
Deposit date:2016-04-13
Release date:2016-05-18
Last modified:2022-02-09
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Structure of Lys27-linked triubiquitin
To Be Published
5J8P
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BU of 5j8p by Molmil
Lys27-linked diubiquitin
Descriptor: D-ubiquitin, MAGNESIUM ION, ubiquitin
Authors:Pan, M, Gao, S, Zheng, Y.
Deposit date:2016-04-08
Release date:2016-05-18
Last modified:2022-02-09
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Structure of Lys27-linked diubiquitin
To Be Published
5JBY
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BU of 5jby by Molmil
Lys27-linked triubiquitin
Descriptor: D-ubiquitin, ubiquitin
Authors:Pan, M, Gao, S, Zheng, Y.
Deposit date:2016-04-14
Release date:2016-07-20
Last modified:2022-02-09
Method:X-RAY DIFFRACTION (1.987 Å)
Cite:Structure of Lys27-linked triubiquitin
To Be Published

221051

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