4COH
Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor
Summary for 4COH
Entry DOI | 10.2210/pdb4coh/pdb |
Descriptor | STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, 2-fluoranyl-N-[(2R)-3-(1H-indol-3-yl)-1-oxidanylidene-1-(pyridin-4-ylamino)propan-2-yl]-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide, ... (4 entities in total) |
Functional Keywords | transferase, cyp51, sterol 14-demethylase, sterol biosynthesis, chagas disease |
Biological source | TRYPANOSOMA CRUZI |
Total number of polymer chains | 2 |
Total formula weight | 109698.68 |
Authors | Vieira, D.F.,Choi, J.Y.,Roush, W.R.,Podust, L.M. (deposition date: 2014-01-28, release date: 2014-04-02, Last modification date: 2023-12-20) |
Primary citation | Vieira, D.F.,Choi, J.Y.,Roush, W.R.,Podust, L.M. Expanding the Binding Envelope of Cyp51 Inhibitors Targeting Trypanosoma Cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives Chembiochem, 15:1111-, 2014 Cited by PubMed: 24771705DOI: 10.1002/CBIC.201402027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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