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5LGE

Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032

Summary for 5LGE
Entry DOI10.2210/pdb5lge/pdb
DescriptorIsocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsidh1, allosteric inhibitor, nadp+, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : O75874
Total number of polymer chains4
Total formula weight196600.72
Authors
Hillig, R.C.,Hars, U.,Korndoerfer, I.P. (deposition date: 2016-07-07, release date: 2017-02-08, Last modification date: 2024-01-10)
Primary citationPusch, S.,Krausert, S.,Fischer, V.,Balss, J.,Ott, M.,Schrimpf, D.,Capper, D.,Sahm, F.,Eisel, J.,Beck, A.C.,Jugold, M.,Eichwald, V.,Kaulfuss, S.,Panknin, O.,Rehwinkel, H.,Zimmermann, K.,Hillig, R.C.,Guenther, J.,Toschi, L.,Neuhaus, R.,Haegebart, A.,Hess-Stumpp, H.,Bauser, M.,Wick, W.,Unterberg, A.,Herold-Mende, C.,Platten, M.,von Deimling, A.
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
Acta Neuropathol., 133:629-644, 2017
Cited by
PubMed: 28124097
DOI: 10.1007/s00401-017-1677-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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