6APT

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)

Summary for 6APT

• Entry DOI: 10.2210/pdb6apt/pdb
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid), DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: trypanosoma brucei, purine salvage, acyclic nucleoside biphosphonate, transferase
• Biological source: Trypanosoma brucei brucei
• Cellular location: Cytoplasm: Q07010
• Total number of polymer chains: 2
• Total formula weight: 49538.33

Authors

Teran, D.,Guddat, L.W. (deposition date: 2017-08-17, release date: 2018-03-14, Last modification date: 2023-10-04)

• Primary citation: Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A.; Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.; PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018; PubMed: 29481567; DOI: 10.1371/journal.pntd.0006301

Experimental method

X-RAY DIFFRACTION (1.795 Å)