6APT
Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| A | 0097014 | cellular_component | ciliary plasm |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0097014 | cellular_component | ciliary plasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 45T A 301 |
| Chain | Residue |
| A | LYS54 |
| A | VAL165 |
| A | PHE166 |
| A | VAL167 |
| A | LEU172 |
| A | ASP173 |
| A | ARG179 |
| A | HOH402 |
| A | HOH408 |
| A | HOH419 |
| A | HOH428 |
| A | GLY55 |
| A | HOH444 |
| A | ILE115 |
| A | ASP117 |
| A | THR118 |
| A | ALA119 |
| A | LEU120 |
| A | THR121 |
| A | LYS145 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PEG A 302 |
| Chain | Residue |
| A | GLU17 |
| A | HIS21 |
| A | HIS21 |
| A | ASP62 |
| A | ASP62 |
| A | ARG65 |
| A | ILE66 |
| A | ARG182 |
| A | HOH430 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue 45T B 301 |
| Chain | Residue |
| B | LYS54 |
| B | GLY55 |
| B | ILE115 |
| B | ASP117 |
| B | THR118 |
| B | ALA119 |
| B | LEU120 |
| B | THR121 |
| B | LYS145 |
| B | VAL165 |
| B | PHE166 |
| B | VAL167 |
| B | LEU172 |
| B | ASP173 |
| B | ARG179 |
| B | HOH405 |
| B | HOH420 |
| B | HOH423 |
| B | HOH432 |
| B | HOH440 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PEG B 302 |
| Chain | Residue |
| B | GLU17 |
| B | HIS21 |
| B | HIS21 |
| B | ARG65 |
| B | ILE66 |
| B | ARG182 |
| B | HOH403 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLVLEDILDTAlT |
| Chain | Residue | Details |
| A | VAL109-THR121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP117 | |
| B | ASP117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS54 | |
| A | GLU113 | |
| A | LYS145 | |
| A | ASP173 | |
| B | LYS54 | |
| B | GLU113 | |
| B | LYS145 | |
| B | ASP173 |
