6X4K

PANK3 complex structure with compound PZ-2890

Summary for 6X4K

• Entry DOI: 10.2210/pdb6x4k/pdb
• Descriptor: Pantothenate kinase 3, 4-(6-cyanopyridazin-3-yl)-N-[4-(propan-2-yl)phenyl]-3,4-dihydropyrazine-1(2H)-carboxamide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (7 entities in total)
• Functional Keywords: pank, substrate, complex, transferase, pantothenate kinase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 43164.24

Authors

White, S.W.,Yun, M. (deposition date: 2020-05-22, release date: 2021-11-24, Last modification date: 2023-10-18)

• Primary citation: Sharma, L.K.,Yun, M.K.,Subramanian, C.,Tangallapally, R.,Jackowski, S.,Rock, C.O.,White, S.W.,Lee, R.E.; LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.; Bioorg.Med.Chem., 52:116504-116504, 2021; PubMed: 34814071; DOI: 10.1016/j.bmc.2021.116504

Experimental method

X-RAY DIFFRACTION (2.1 Å)