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3QAZ	IL-2 mutant D10 ternary complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ... Authors: Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C. Deposit date: 2011-01-12 Release date: 2012-04-11 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.802 Å) Cite: Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
5M5E	Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Klein, C, Freimoser-Grundschober, A, Waldhauer, I, Stihle, M, Birk, M, Benz, J. Deposit date: 2016-10-21 Release date: 2017-05-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology, 6, 2017
7ZMZ	Engineered Interleukin 2 bound to CD25 receptor Descriptor: Interleukin-2, Interleukin-2 receptor subunit alpha Authors: Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S. Deposit date: 2022-04-20 Release date: 2022-12-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.2 Å) Cite: IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol, 7, 2022
6VWU	X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha Descriptor: Interleukin-2,Interleukin-2 receptor subunit alpha Authors: Losey, H.C. Deposit date: 2020-02-20 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.4 Å) Cite: ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer, 8, 2020
1Z92	structure of interleukin-2 with its alpha receptor Descriptor: Interleukin-2, Interleukin-2 receptor alpha chain Authors: Rickert, M, Wang, X.Q, Goriatcheva, N, Boulanger, M.J, Garcia, K.C. Deposit date: 2005-03-31 Release date: 2005-06-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The structure of interleukin-2 complexed with its alpha receptor. Science, 308, 2005
2B5I	cytokine receptor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... Authors: Wang, X, Rickert, M, Garcia, K.C. Deposit date: 2005-09-28 Release date: 2005-11-29 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science, 310, 2005
2ERJ	Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Debler, E.W, Stauber, D.J, Wilson, I.A. Deposit date: 2005-10-25 Release date: 2006-02-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc.Natl.Acad.Sci.Usa, 103, 2006

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