7D8P
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6A5Q
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7O3S
| 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-045 | Descriptor: | 14-3-3 protein sigma, 3-methoxy-1-(4-methylphenyl)sulfonyl-azetidine, CHLORIDE ION, ... | Authors: | Wolter, M, Ottmann, C. | Deposit date: | 2021-04-02 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
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7O6F
| 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-178 | Descriptor: | 14-3-3 protein sigma, 4-[4-(2-hydroxyethyl)piperidin-1-yl]carbonylbenzaldehyde, CALCIUM ION, ... | Authors: | Wolter, M, Ottmann, C. | Deposit date: | 2021-04-11 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
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1QJA
| 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) | Descriptor: | 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE | Authors: | Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. | Deposit date: | 1999-06-23 | Release date: | 1999-09-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
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3SMM
| Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... | Authors: | Anders, C, Schumacher, B, Ottmann, C. | Deposit date: | 2011-06-28 | Release date: | 2012-07-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
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7QIK
| SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma | Descriptor: | 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | Authors: | Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. | Deposit date: | 2021-12-15 | Release date: | 2021-12-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
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6YMO
| Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide | Descriptor: | 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... | Authors: | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | Deposit date: | 2020-04-09 | Release date: | 2021-03-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
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6T5H
| Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 | Descriptor: | 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... | Authors: | Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. | Deposit date: | 2019-10-16 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
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4JC3
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6YOX
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6YGJ
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5NWJ
| 14-3-3c in complex with CPP7 | Descriptor: | 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. | Deposit date: | 2017-05-06 | Release date: | 2017-11-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
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3EFZ
| Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein | Authors: | Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-10 | Release date: | 2008-09-23 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
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5NAS
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6YO8
| Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide | Descriptor: | 14-3-3 protein zeta/delta, Glucocorticoid receptor | Authors: | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | Deposit date: | 2020-04-14 | Release date: | 2021-03-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
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6A5S
| Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif | Descriptor: | 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... | Authors: | Xu, Y, Ren, J.Q, Feng, W. | Deposit date: | 2018-06-25 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
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7OBY
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8BWH
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5YQG
| The structure of 14-3-3 and pNumb peptide | Descriptor: | 14-3-3 protein eta, Peptide from Protein numb homolog | Authors: | Chen, X, Liu, Z, Wen, W. | Deposit date: | 2017-11-06 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem., 293, 2018
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5D2D
| Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 | Descriptor: | 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... | Authors: | Stevers, L.M, Leysen, S.F.R, Ottmann, C. | Deposit date: | 2015-08-05 | Release date: | 2016-03-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
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4JDD
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3SMK
| Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A | Descriptor: | 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ... | Authors: | Anders, C, Schumacher, B, Ottmann, C. | Deposit date: | 2011-06-28 | Release date: | 2012-07-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
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6YR7
| 14-3-3 sigma in complex with hDMX-342+367 peptide | Descriptor: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 | Authors: | Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. | Deposit date: | 2020-04-19 | Release date: | 2021-11-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
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6FNC
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