PDB: 244693 resultsInfo pagesStatus searchChemie searchBIRD

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1XMN	Crystal structure of thrombin bound to heparin Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... Authors: Carter, W.J, Cama, E, Huntington, J.A. Deposit date: 2004-10-04 Release date: 2004-11-23 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of thrombin bound to heparin J.Biol.Chem., 280, 2005
9Q1N	Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Descriptor: 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one, Transcriptional enhancer factor TEF-4 Authors: Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O. Deposit date: 2025-08-14 Release date: 2025-09-03 Last modified: 2025-10-01 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells. Acs Chem.Biol., 20, 2025
7WQQ	Retinoic acid receptor alpha mutant - N299H Descriptor: 4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxidanylidene-prop-1-enyl]benzoic acid, Peptide from Nuclear receptor coactivator 1, Retinoic acid receptor alpha Authors: Huang, X.X, Ng, L.M, Teh, B.T. Deposit date: 2022-01-25 Release date: 2023-01-25 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling To Be Published
7WUP	The crystal structure of ApiI Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ApiI, ... Authors: Zhou, J, Lu, J. Deposit date: 2022-02-09 Release date: 2023-02-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The crystal structure of ApiI To Be Published
7WVS	The structure of FinI complex with SAM Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Methyltransf_2 domain-containing protein, ... Authors: Lu, J, Zhou, J. Deposit date: 2022-02-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The structure of FinI complex with SAM To Be Published
2LXI	NMR structure of the N-terminal RNA Binding domain 1 (RRM1) of the protein RBM10 from Homo sapiens Descriptor: RNA-binding protein 10 Authors: Serrano, P, Geralt, M, Dutta, S.K, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-08-27 Release date: 2012-10-10 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR structure of the N-terminal RNA Binding domain 1 (RRM1) of the protein RBM10 from Homo sapiens To be Published
9PSE	In situ MicroED structure of IL-5 activated human eosinophil major basic protein-1 Descriptor: Bone marrow proteoglycan, CHLORIDE ION Authors: Yang, J.E, Bingman, C.A, Mitchell, J, Mosher, D, Wright, E.R. Deposit date: 2025-07-25 Release date: 2025-09-03 Method: ELECTRON CRYSTALLOGRAPHY (3.18 Å) Cite: In situ microED structure of the Eosinophil major basic protein-1 To Be Published
7XCT	Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex Descriptor: DNA (145-MER), Histone H2A, Histone H2B type 1-K, ... Authors: Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. Deposit date: 2022-03-25 Release date: 2022-04-20 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022
7XIJ	Crystal structure of CBP bromodomain liganded with Y08175 Descriptor: 3-[(1-ethanoyl-5-methoxy-indol-3-yl)carbonylamino]-4-fluoranyl-5-(1-methylpyrazol-4-yl)benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Xiang, Q, Wang, C, Wu, T, Zhang, Y, Zhang, C, Luo, G, Wu, X, Shen, H, Xu, Y. Deposit date: 2022-04-13 Release date: 2022-06-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Crystal structure of CBP bromodomain liganded with Y08175 To Be Published
4WUV	Crystal Structure of a putative D-Mannonate oxidoreductase from Haemophilus influenza (Avi_5165, TARGET EFI-513796) with bound NAD Descriptor: 1,2-ETHANEDIOL, 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C. Deposit date: 2014-11-03 Release date: 2014-11-26 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.551 Å) Cite: Crystal structure of a putative D-Mannonate oxidoreductase from Haemophilus influenza (Avi_5165, TARGET EFI-513796) with bound NAD To be published
9NKF	Structure of human substrate-free 26S proteasome in the presence of ATPgS and MG-132,SA-like state (composite map) Descriptor: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ... Authors: Peddada, N, Beutler, B. Deposit date: 2025-02-28 Release date: 2025-05-07 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural insights into the ubiquitin-independent midnolin-proteasome pathway. Proc.Natl.Acad.Sci.USA, 122, 2025
9NKJ	Structure of substrates-engaged MIDN-bound human 26S proteasome,ED-MIDN state (Composite map) Descriptor: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ... Authors: Peddada, N, Beutler, B. Deposit date: 2025-02-28 Release date: 2025-05-07 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural insights into the ubiquitin-independent midnolin-proteasome pathway. Proc.Natl.Acad.Sci.USA, 122, 2025
9NKG	Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map) Descriptor: 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, ... Authors: Peddada, N, Beutler, B. Deposit date: 2025-02-28 Release date: 2025-05-07 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural insights into the ubiquitin-independent midnolin-proteasome pathway. Proc.Natl.Acad.Sci.USA, 122, 2025
9NIG	PB TCR in complex with HLA-DR4 presenting citrullinated Tenascin C peptide Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Dao, H.T, Loh, T.J, Lim, J.J, Rossjohn, J. Deposit date: 2025-02-26 Release date: 2025-05-21 Method: X-RAY DIFFRACTION (3.20008039 Å) Cite: PB TCR in complex with HLA-DR4 presenting citrullinated Tenascin C peptide To Be Published
2MA6	Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A Descriptor: E3 ubiquitin-protein ligase RNF123, ZINC ION Authors: Ramelot, T.A, Yang, Y, Janjua, H, Kohan, E, Wang, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) Deposit date: 2013-06-28 Release date: 2013-07-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A To be Published
7QTI	SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, ... Authors: Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D. Deposit date: 2022-01-14 Release date: 2022-08-03 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys. Nat Microbiol, 7, 2022
7WUG	GID subcomplex: Gid12 bound Substrate Receptor Scaffolding module Descriptor: Glucose-induced degradation protein 8, HLJ1_G0042170.mRNA.1.CDS.1, Vacuolar import and degradation protein 24, ... Authors: Qiao, S, Cheng, J.D, Schulman, B.A. Deposit date: 2022-02-08 Release date: 2022-06-08 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nat Commun, 13, 2022
2M0D	Solution Structure of Miz-1 zinc finger 5 Descriptor: ZINC ION, Zinc finger and BTB domain-containing protein 17 Authors: Bernard, D, Bedard, M, Bilodeau, J, Lavigne, P. Deposit date: 2012-10-24 Release date: 2012-11-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structure Note: Structure of Miz-1 Zinc Fingers 5 to 7 To be Published
7W7E	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist Descriptor: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. Deposit date: 2021-12-04 Release date: 2022-09-28 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
2M0Z	cis form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative Descriptor: 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Tyrosine-protein phosphatase non-receptor type 13 Authors: Walser, R, Zerbe, O, Hamm, P. Deposit date: 2012-11-09 Release date: 2013-07-03 Last modified: 2025-03-26 Method: SOLUTION NMR Cite: Kinetic response of a photoperturbed allosteric protein. Proc.Natl.Acad.Sci.USA, 110, 2013
6CUF	Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Acharya, P, Carragher, B, Potter, C.S, Kwong, P.D. Deposit date: 2018-03-26 Release date: 2018-07-25 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (4 Å) Cite: Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog., 14, 2018
9O9V	NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C1 Reconstruction] Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NCS.1.1 Heavy Chain, ... Authors: Borst, A.J. Deposit date: 2025-04-18 Release date: 2025-08-13 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies. Nat Commun, 16, 2025
9OG5	SARS-COV-2-6P-MUT7 S PROTEIN-DY-III-281 complex 1 RBD up conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... Authors: Chandravanshi, M, Niu, L, Tolbert, W.D, Pazgier, M. Deposit date: 2025-04-30 Release date: 2025-10-01 Last modified: 2025-10-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants. J.Virol., 2025
9O2Q	BG505-DS SOSIP in complex with 007 bNAb Fabs - Class 0 (unbound) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: DeLaitsch, A.T, Bjorkman, P.J. Deposit date: 2025-04-04 Release date: 2025-10-01 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Identification of a broad and potent V3 glycan site bNAb targeting an N332 gp120 glycan-independent epitope. Biorxiv, 2025
7XCR	Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex Descriptor: DNA (146-MER), Histone H2A, Histone H2B type 1-K, ... Authors: Ai, H.S, Liu, A.J, Lou, Z.Y, Liu, L. Deposit date: 2022-03-25 Release date: 2022-04-20 Last modified: 2025-06-25 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat.Chem.Biol., 18, 2022

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