7XCT

Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex

Summary for 7XCT

• Entry DOI: 10.2210/pdb7xct/pdb
• EMDB information: 33127
• Descriptor: Ubiquitin, Histone H4, Histone H2A, ... (9 entities in total)
• Functional Keywords: complex, dot1l, h2bk34ub, nucleosome, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 14
• Total formula weight: 271315.24

Authors

Ai, H.S.,Liu, A.J.,Lou, Z.Y.,Liu, L. (deposition date: 2022-03-25, release date: 2022-04-20, Last modification date: 2022-09-07)

• Primary citation: Ai, H.,Sun, M.,Liu, A.,Sun, Z.,Liu, T.,Cao, L.,Liang, L.,Qu, Q.,Li, Z.,Deng, Z.,Tong, Z.,Chu, G.,Tian, X.,Deng, H.,Zhao, S.,Li, J.B.,Lou, Z.,Liu, L.; H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity.; Nat.Chem.Biol., 18:972-980, 2022; PubMed: 35739357; DOI: 10.1038/s41589-022-01067-7

Experimental method

ELECTRON MICROSCOPY (2.72 Å)