7XCT
Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L, N | Ubiquitin | polymer | 76 | 8576.8 | 2 | UniProt (P0CG47) Pfam (PF00240) In PDB | Homo sapiens (human) | |
2 | F, B | Histone H4 | polymer | 89 | 10193.0 | 2 | UniProt (A0A3P9NC92) Pfam (PF15511) UniProt (by SIFTS) (P62805) In PDB | Homo sapiens (human) | |
3 | G, C | Histone H2A | polymer | 108 | 11865.9 | 2 | UniProt (Q08AJ9) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P04908) In PDB | Homo sapiens (human) | |
4 | H, D | Histone H2B type 1-K | polymer | 93 | 10320.8 | 2 | UniProt (O60814) Pfam (PF00125) In PDB | Homo sapiens (human) | H2B K,HIRA-interacting protein 1 |
5 | K, M | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 328 | 37930.0 | 2 | UniProt (Q8TEK3) Pfam (PF08123) In PDB | Homo sapiens (human) | DOT1-like protein |
6 | E, A | Histone domain-containing protein | polymer | 99 | 11615.6 | 2 | UniProt (S4RAZ3) Pfam (PF00125) UniProt (by SIFTS) (Q71DI3) In PDB | Homo sapiens | |
7 | I | DNA (145-MER) | polymer | 145 | 44521.4 | 1 | synthetic construct | ||
8 | J | DNA (145-MER) | polymer | 145 | 44992.6 | 1 | synthetic construct | ||
9 | K, M | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) |
Sequence modifications
F, B: 15 - 102 (UniProt: A0A3P9NC92)
E, A: 37 - 135 (UniProt: S4RAZ3)
PDB | External Database | Details |
---|---|---|
Met 14 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Nle 79 | Lys 103 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 14 |
Total formula weight | 270518.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 796.9 | |
All* | Total formula weight | 271315.2 |