6I1E
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![BU of 6i1e by Molmil](/molmil-images/mine/6i1e) | Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin | Descriptor: | 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Peptidoglycan D,D-transpeptidase FtsI | Authors: | Bellini, D, Dowson, C.G. | Deposit date: | 2018-10-28 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance. J.Mol.Biol., 431, 2019
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6N1N
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![BU of 6n1n by Molmil](/molmil-images/mine/6n1n) | Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386 | Descriptor: | Beta-lactamase, GLYCEROL, SULFATE ION | Authors: | Michalska, K, Tesar, C, Endres, M, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-11-09 | Release date: | 2018-12-19 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386 To Be Published
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6I5D
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![BU of 6i5d by Molmil](/molmil-images/mine/6i5d) | Crystal structure of an OXA-48 beta-lactamase synthetic mutant | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Zavala, A, Retailleau, P, Dabos, L, Naas, T, Iorga, B. | Deposit date: | 2018-11-13 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Substrate specificity of an OXA-48 beta-lactamase synthetic mutant To be published
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6N6W
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![BU of 6n6w by Molmil](/molmil-images/mine/6n6w) | OXA-23 mutant F110A/M221A neutral pH form | Descriptor: | Beta-lactamase oxa23 | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2018-11-27 | Release date: | 2018-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases. Antimicrob. Agents Chemother., 63, 2019
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6N6V
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![BU of 6n6v by Molmil](/molmil-images/mine/6n6v) | |
6N6Y
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![BU of 6n6y by Molmil](/molmil-images/mine/6n6y) | |
6N6T
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![BU of 6n6t by Molmil](/molmil-images/mine/6n6t) | OXA-23 mutant F110A/M221A low pH form | Descriptor: | Beta-lactamase oxa23, CITRATE ANION | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2018-11-27 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases. Antimicrob. Agents Chemother., 63, 2019
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6N6X
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![BU of 6n6x by Molmil](/molmil-images/mine/6n6x) | |
6N6U
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![BU of 6n6u by Molmil](/molmil-images/mine/6n6u) | |
6Q5B
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![BU of 6q5b by Molmil](/molmil-images/mine/6q5b) | OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, CARBON DIOXIDE, ... | Authors: | Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.K.S, Samuelsen, O. | Deposit date: | 2018-12-07 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
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6Q5F
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![BU of 6q5f by Molmil](/molmil-images/mine/6q5f) | OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance | Descriptor: | 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Beta-lactamase, CHLORIDE ION, ... | Authors: | Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.-K.S, Samuelsen, O. | Deposit date: | 2018-12-08 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
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6Q9N
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![BU of 6q9n by Molmil](/molmil-images/mine/6q9n) | Crystal structure of PBP2a from MRSA in complex with piperacillin and quinazolinone | Descriptor: | 3-[2-[(~{E})-2-(4-ethynylphenyl)ethenyl]-4-oxidanylidene-quinazolin-3-yl]benzoic acid, CADMIUM ION, CHLORIDE ION, ... | Authors: | Martinez-Caballero, S, Batuecas, M.T, Hermoso, J.A. | Deposit date: | 2018-12-18 | Release date: | 2019-11-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63, 2019
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6NHU
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![BU of 6nhu by Molmil](/molmil-images/mine/6nhu) | Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | Authors: | Kim, Y, Welk, L, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-12-23 | Release date: | 2019-01-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum To Be Published
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6NHS
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![BU of 6nhs by Molmil](/molmil-images/mine/6nhs) | Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Kim, Y, Tesar, C, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-12-23 | Release date: | 2019-01-16 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Beta Lactamase Class D YbXI from Nostoc To Be Published
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6NLW
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![BU of 6nlw by Molmil](/molmil-images/mine/6nlw) | The crystal structure of class D carbapenem-hydrolyzing beta-lactamase BlaA from Shewanella oneidensis MR-1 | Descriptor: | Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Tan, K, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2019-01-09 | Release date: | 2019-01-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The crystal structure of class D carbapenem-hydrolyzing beta-lactamase BlaA from Shewanella oneidensis MR-1 To Be Published
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6NZ8
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![BU of 6nz8 by Molmil](/molmil-images/mine/6nz8) | Structure of carbamylated apo OXA-231 carbapenemase | Descriptor: | Beta-lactamase OXA-231, CHLORIDE ION, SODIUM ION | Authors: | Favaro, D.C, Llontop, E.E, Vasconcelos, F.N, Antunes, V.U, Farah, S.C, Lincopan, N. | Deposit date: | 2019-02-13 | Release date: | 2020-02-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Importance of the beta 5-beta 6 Loop for the Structure, Catalytic Efficiency, and Stability of Carbapenem-Hydrolyzing Class D beta-Lactamase Subfamily OXA-143. Biochemistry, 58, 2019
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6O9S
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![BU of 6o9s by Molmil](/molmil-images/mine/6o9s) | |
6O9W
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![BU of 6o9w by Molmil](/molmil-images/mine/6o9w) | |
6R40
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![BU of 6r40 by Molmil](/molmil-images/mine/6r40) | |
6R3X
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![BU of 6r3x by Molmil](/molmil-images/mine/6r3x) | |
6R42
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![BU of 6r42 by Molmil](/molmil-images/mine/6r42) | |
6RJ7
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![BU of 6rj7 by Molmil](/molmil-images/mine/6rj7) | Crystal structure of the 19F labelled OXA-48 | Descriptor: | Beta-lactamase, CALCIUM ION, CHLORIDE ION | Authors: | Brem, J, Lohans, C, Schofield, C. | Deposit date: | 2019-04-26 | Release date: | 2019-07-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.73002231 Å) | Cite: | 19F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D beta-Lactamase Carbamylation and Inhibition. Chemistry, 25, 2019
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6RTN
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![BU of 6rtn by Molmil](/molmil-images/mine/6rtn) | Crystal structure of OXA-10 with VNRX-5133 | Descriptor: | (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Beta-lactamase OXA-10, CHLORIDE ION | Authors: | Brem, J, Schofield, C. | Deposit date: | 2019-05-24 | Release date: | 2019-09-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases. J.Med.Chem., 62, 2019
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6P56
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6P52
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![BU of 6p52 by Molmil](/molmil-images/mine/6p52) | |