6Q9N

Crystal structure of PBP2a from MRSA in complex with piperacillin and quinazolinone

Summary for 6Q9N

• Entry DOI: 10.2210/pdb6q9n/pdb
• Descriptor: Penicillin binding protein 2 prime, 3-[2-[(~{E})-2-(4-ethynylphenyl)ethenyl]-4-oxidanylidene-quinazolin-3-yl]benzoic acid, Piperacillin (Open Form), ... (7 entities in total)
• Functional Keywords: penicillin binding protein, hydrolase
• Biological source: Staphylococcus aureus (strain Mu50 / ATCC 700699)
• Total number of polymer chains: 2
• Total formula weight: 148327.98

Authors

Martinez-Caballero, S.,Batuecas, M.T.,Hermoso, J.A. (deposition date: 2018-12-18, release date: 2019-11-27, Last modification date: 2024-01-24)

• Primary citation: Janardhanan, J.,Bouley, R.,Martinez-Caballero, S.,Peng, Z.,Batuecas-Mordillo, M.,Meisel, J.E.,Ding, D.,Schroeder, V.A.,Wolter, W.R.,Mahasenan, K.V.,Hermoso, J.A.,Mobashery, S.,Chang, M.; The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 30858202; DOI: 10.1128/AAC.02637-18

Experimental method

X-RAY DIFFRACTION (2.5 Å)