2QVS
 
 | | Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase | | Descriptor: | cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase, alpha-catalytic subunit | | Authors: | Wu, J, Brown, S.H.J, von Daake, S, Taylor, S.S. | | Deposit date: | 2007-08-08 | | Release date: | 2007-10-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science, 318, 2007
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2QCS
 | | A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state | | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. | | Deposit date: | 2007-06-19 | | Release date: | 2007-11-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell(Cambridge,Mass.), 130, 2007
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2Q0A
 | | Structure and rearrangements in the carboxy-terminal region of SpIH channels | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N. | | Deposit date: | 2007-05-21 | | Release date: | 2007-06-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
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2PTM
 | | Structure and rearrangements in the carboxy-terminal region of SpIH channels | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, COBALT HEXAMMINE(III), Hyperpolarization-activated (Ih) channel | | Authors: | Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N. | | Deposit date: | 2007-05-08 | | Release date: | 2007-06-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
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2PQQ
 | | Structural Genomics, the crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2) | | Descriptor: | FORMIC ACID, Putative transcriptional regulator | | Authors: | Tan, K, Xu, X, Zheng, H, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-05-02 | | Release date: | 2007-06-05 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2)
To be Published
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2OZ6
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2N7G
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2MPF
 | | Solution structure human HCN2 CNBD in the cAMP-unbound state | | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A. | | Deposit date: | 2014-05-16 | | Release date: | 2014-09-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc.Natl.Acad.Sci.USA, 111, 2014
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2MNG
 | | Apo Structure of human HCN4 CNBD solved by NMR | | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | Authors: | Akimoto, M, Zhang, Z, Boulton, S, Selvaratnam, R, VanSchouwen, B, Gloyd, M, Accili, E.A, Lange, O.F, Melacini, G. | | Deposit date: | 2014-04-03 | | Release date: | 2014-06-04 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.
J.Biol.Chem., 289, 2014
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2MHF
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2KXL
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2K0G
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2HKX
 | | Structure of CooA mutant (N127L/S128L) from Carboxydothermus hydrogenoformans | | Descriptor: | CARBON MONOXIDE, Carbon monoxide oxidation system transcription regulator CooA-1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Lanz, N.D, Borjigin, M, Li, H, Kerby, R.L, Poulos, T.L, Roberts, G.P. | | Deposit date: | 2006-07-05 | | Release date: | 2007-03-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA.
Acta Crystallogr.,Sect.D, 63, 2007
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2H6C
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2H6B
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2GZW
 | | Crystal structure of the E.coli CRP-cAMP complex | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | | Authors: | Kumarevel, T.S, Tanaka, T, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-05-12 | | Release date: | 2007-05-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Crystal structure of activated CRP protein from E coli
To be Published
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2GAU
 | | Crystal structure of transcriptional regulator, Crp/Fnr family from Porphyromonas gingivalis (APC80792), Structural genomics, MCSG | | Descriptor: | transcriptional regulator, Crp/Fnr family | | Authors: | Rotella, F.J, Zhang, R.G, Mulligan, R, Moy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2006-03-09 | | Release date: | 2006-04-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The 1.9-A crystal structure of transcriptional regulator, Crp/Fnr family from Porphyromonas gingivalis
To be Published
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2FMY
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2D93
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2CGP
 | | CATABOLITE GENE ACTIVATOR PROTEIN/DNA COMPLEX, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*AP*AP*TP*GP*TP*GP*AP*CP*AP*TP*AP*T)-3'), DNA (5'-D(*GP*TP*CP*AP*CP*AP*TP*TP*AP*AP*T)-3'), ... | | Authors: | Passner, J.M, Steitz, T.A. | | Deposit date: | 1997-01-31 | | Release date: | 1998-02-04 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer.
Proc.Natl.Acad.Sci.USA, 94, 1997
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2BYV
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1ZYB
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1ZRF
 | | 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6C;17G]ICAP38 DNA | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ... | | Authors: | Berman, H.M, Napoli, A.A. | | Deposit date: | 2005-05-19 | | Release date: | 2006-03-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps.
J.Mol.Biol., 357, 2006
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1ZRE
 | | 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6G;17C]ICAP38 DNA | | Descriptor: | 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*GP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*CP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | Authors: | Berman, H.M, Napoli, A.A. | | Deposit date: | 2005-05-19 | | Release date: | 2006-03-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps.
J.Mol.Biol., 357, 2006
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1ZRD
 | | 4 crystal structures of CAP-DNA with all base-pair substitutions at position 6, CAP-[6A;17T]ICAP38 DNA | | Descriptor: | 5'-D(*AP*TP*TP*TP*CP*GP*AP*AP*AP*AP*AP*TP*GP*AP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*TP*CP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | | Authors: | Berman, H.M, Napoli, A.A. | | Deposit date: | 2005-05-19 | | Release date: | 2006-03-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps.
J.Mol.Biol., 357, 2006
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