Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state

Summary for 2BYV

DescriptorRAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 (2 entities in total)
Functional Keywordsepac2, camp-gef2, camp, cyclic nucleotide, gef, exchange factor, regulation, auto-inhibition, cdc25 homology domain
Biological sourceMUS MUSCULUS (MOUSE)
Cellular locationCytoplasm Q9EQZ6
Total number of polymer chains1
Total molecular weight114150.55
Rehmann, H.,Wittinghofer, A.,Bos, J.L. (deposition date: 2005-08-08, release date: 2006-02-02, Last modification date: 2011-07-13)
Primary citation
Rehmann, H.,Das, J.,Knipscheer, P.,Wittinghofer, A.,Bos, J.L.
Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439:625-, 2006
PubMed: 16452984 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE04468
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29221.2%2.9%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2byv
no rotation
Molmil generated image of 2byv
rotated about x axis by 90°
Molmil generated image of 2byv
rotated about y axis by 90°