2BYV

Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000166	molecular_function	nucleotide binding
E	0001750	cellular_component	photoreceptor outer segment
E	0001917	cellular_component	photoreceptor inner segment
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005903	cellular_component	brush border
E	0006887	biological_process	exocytosis
E	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0007265	biological_process	Ras protein signal transduction
E	0014069	cellular_component	postsynaptic density
E	0014911	biological_process	positive regulation of smooth muscle cell migration
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0016324	cellular_component	apical plasma membrane
E	0017156	biological_process	calcium-ion regulated exocytosis
E	0017157	biological_process	regulation of exocytosis
E	0030073	biological_process	insulin secretion
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0030426	cellular_component	growth cone
E	0030552	molecular_function	cAMP binding
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031267	molecular_function	small GTPase binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0032991	cellular_component	protein-containing complex
E	0035556	biological_process	intracellular signal transduction
E	0043025	cellular_component	neuronal cell body
E	0043197	cellular_component	dendritic spine
E	0044316	cellular_component	cone cell pedicle
E	0044877	molecular_function	protein-containing complex binding
E	0046879	biological_process	hormone secretion
E	0050714	biological_process	positive regulation of protein secretion
E	0050773	biological_process	regulation of dendrite development
E	0050805	biological_process	negative regulation of synaptic transmission
E	0060076	cellular_component	excitatory synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098693	biological_process	regulation of synaptic vesicle cycle
E	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
E	0098978	cellular_component	glutamatergic synapse
E	0099175	biological_process	regulation of postsynapse organization
E	1904457	biological_process	positive regulation of neuronal action potential

Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	30
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK

Chain	Residue	Details
E	ILE903-LYS932

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O95398

Chain	Residue	Details
E	GLU422
E	LYS432

---