3ZFK
| N-terminal truncated Nuclease Domain of Colicin E7 | Descriptor: | ACETATE ION, CHLORIDE ION, COLICIN-E7, ... | Authors: | Toth, E, Czene, A, Gyurcsik, B, Otten, H, Poulsen, J.-C.N, Larsen, S, Christensen, H.E.M, Nagata, K. | Deposit date: | 2012-12-11 | Release date: | 2013-12-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A New Insight Into the Zinc-Dependent DNA-Cleavage by the Colicin E7 Nuclease: A Crystallographic and Computational Study. Metallomics, 6, 2014
|
|
4M63
| Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Tomchick, D.R, Zahm, J.A, Rosen, M.K. | Deposit date: | 2013-08-08 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.748 Å) | Cite: | The Bacterial Effector VopL Organizes Actin into Filament-like Structures. Cell(Cambridge,Mass.), 155, 2013
|
|
5AZV
| Crystal structure of hPPARgamma ligand binding domain complexed with 17-oxoDHA | Descriptor: | (4~{Z},7~{Z},10~{Z},13~{Z},19~{Z})-17-oxidanylidenedocosa-4,7,10,13,19-pentaenoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Egawa, D, Itoh, T, Yamamoto, K. | Deposit date: | 2015-10-23 | Release date: | 2016-07-06 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | 17-OxoDHA Is a PPAR alpha/gamma Dual Covalent Modifier and Agonist Acs Chem.Biol., 2016
|
|
2B1I
| crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase | Descriptor: | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE | Authors: | Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A. | Deposit date: | 2005-09-15 | Release date: | 2006-11-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. J.Biol.Chem., 282, 2007
|
|
7CP6
| Crystal structure of FqzB | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, IODIDE ION, MAK1-like monooxygenase, ... | Authors: | Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K. | Deposit date: | 2020-08-06 | Release date: | 2020-12-30 | Last modified: | 2021-01-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis. Biochemistry, 59, 2020
|
|
2ATH
| Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist | Descriptor: | 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID, Peroxisome proliferator activated receptor gamma | Authors: | Mahindroo, N, Huang, C.-F, Wu, S.-Y, Hsieh, H.-P. | Deposit date: | 2005-08-25 | Release date: | 2006-08-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities J.Med.Chem., 48, 2005
|
|
4BW1
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | Descriptor: | 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 4 | Authors: | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | Deposit date: | 2013-06-29 | Release date: | 2013-09-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
|
|
4BW3
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | Descriptor: | 1,2-ETHANEDIOL, 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 4 | Authors: | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | Deposit date: | 2013-06-29 | Release date: | 2013-09-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
|
|
4O9C
| Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16 | Descriptor: | Acetyl-CoA acetyltransferase, COENZYME A | Authors: | Kim, E.J, Kim, J, Kim, S, Kim, K.J. | Deposit date: | 2014-01-02 | Release date: | 2014-12-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium. Biochem.Biophys.Res.Commun., 452, 2014
|
|
1ROM
| |
4EU3
| |
3U5L
| Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7) | Descriptor: | 1,2-ETHANEDIOL, 8-chloro-1,4-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine, Bromodomain-containing protein 4 | Authors: | Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bracher, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2011-10-11 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20, 2012
|
|
2MQM
| Structural Investigation of hnRNP L | Descriptor: | Protein Hnrnpl | Authors: | Blatter, M, Allain, F. | Deposit date: | 2014-06-24 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
|
|
2HAX
| |
4NMN
| Aquifex aeolicus replicative helicase (DnaB) complexed with ADP, at 3.3 resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Replicative DNA helicase, ... | Authors: | Lyubimov, A.Y, Strycharska, M.S, Erzberger, J.P, Berger, J.M. | Deposit date: | 2013-11-15 | Release date: | 2014-01-29 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | Nucleotide and partner-protein control of bacterial replicative helicase structure and function. Mol.Cell, 52, 2013
|
|
5AZT
| Ternary complex of hPPARalpha ligand binding domain, 17-oxoDHA and a SRC1 peptide | Descriptor: | (4~{Z},7~{Z},10~{Z},13~{Z},19~{Z})-17-oxidanylidenedocosa-4,7,10,13,19-pentaenoic acid, 15-meric peptide from Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor alpha | Authors: | Egawa, D, Itoh, T, Yamamoto, K. | Deposit date: | 2015-10-23 | Release date: | 2016-07-06 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | 17-OxoDHA Is a PPAR alpha/gamma Dual Covalent Modifier and Agonist Acs Chem.Biol., 2016
|
|
3HBG
| Structure of recombinant Chicken Liver Sulfite Oxidase mutant C185S | Descriptor: | HYDROXY(DIOXO)MOLYBDENUM, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, Sulfite Oxidase mutant C185S | Authors: | Qiu, J.A. | Deposit date: | 2009-05-04 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structures of the C185S and C185A mutants of sulfite oxidase reveal rearrangement of the active site. Biochemistry, 49, 2010
|
|
3KLI
| |
2LK5
| Solution structure of the Zn(II) form of Desulforedoxin | Descriptor: | Desulforedoxin, ZINC ION | Authors: | Goodfellow, B.J, Tavares, P, Romao, M.J, Czaja, C, Rusnak, F, Legall, J, Moura, I, Moura, J.J.G. | Deposit date: | 2011-10-06 | Release date: | 2012-01-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of desulforedoxin, a simple iron-sulfur protein - An NMR study of the zinc derivative J.BIOL.INORG.CHEM., 1, 1996
|
|
3ZNJ
| Crystal structure of unliganded ClcF from R.opacus 1CP in crystal form 1. | Descriptor: | 1,2-ETHANEDIOL, 5-CHLOROMUCONOLACTONE DEHALOGENASE, CHLORIDE ION | Authors: | Roth, C, Groening, J.A.D, Kaschabek, S.R, Schloemann, M, Straeter, N. | Deposit date: | 2013-02-14 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure and Catalytic Mechanism of Chloromuconolactone Dehalogenase Clcf from Rhodococcus Opacus 1Cp. Mol.Microbiol., 88, 2013
|
|
1M3Q
| |
4L4G
| Structure of cyanide and camphor bound P450cam mutant L358P/K178G | Descriptor: | CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... | Authors: | Batabyal, D, Li, H, Poulos, T.L. | Deposit date: | 2013-06-07 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Synergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1. Biochemistry, 52, 2013
|
|
4L2L
| Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine | Descriptor: | 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETATE ION, Leukotriene A-4 hydrolase, ... | Authors: | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | Deposit date: | 2013-06-04 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.648 Å) | Cite: | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
1S2W
| Crystal structure of phosphoenolpyruvate mutase in high ionic strength | Descriptor: | Phosphoenolpyruvate phosphomutase, SULFATE ION | Authors: | Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. | Deposit date: | 2004-01-11 | Release date: | 2004-05-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Conformational Flexibility of PEP Mutase Biochemistry, 43, 2004
|
|
5E4L
| Structure of ligand binding region of uPARAP at pH 5.3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type mannose receptor 2, CALCIUM ION | Authors: | Yuan, C, Huang, M. | Deposit date: | 2015-10-06 | Release date: | 2016-10-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Crystal structures of uPARAP, a member of mannose receptor family to be published
|
|