2ATH

Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist

Summary for 2ATH

• Entry DOI: 10.2210/pdb2ath/pdb
• Descriptor: Peroxisome proliferator activated receptor gamma, 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (3 entities in total)
• Functional Keywords: ppar, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 62946.93

Authors

Mahindroo, N.,Huang, C.-F.,Wu, S.-Y.,Hsieh, H.-P. (deposition date: 2005-08-25, release date: 2006-08-25, Last modification date: 2024-03-13)

• Primary citation: Mahindroo, N.,Huang, C.-F.,Peng, Y.-H.,Wang, C.-C.,Liao, C.-C.,Lien, T.-W.,Chittimalla, S.K.,Huang, W.-J.,Chai, C.-H.,Prakash, E.,Chen, C.-P.,Hsu, T.-A.,Peng, C.-H.,Lu, I.-L.,Lee, L.-H.,Chang, Y.-W.,Chen, W.-C.,Chou, Y.-C.,Chen, C.-T.,Goparaju, C.M.V.,Chen, Y.-S.,Lan, S.-J.,Yu, M.-C.,Chen, X.,Chao, Y.-S.,Wu, S.-Y.,Hsieh, H.-P.; Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities; J.Med.Chem., 48:8194-8208, 2005; PubMed: 16366601; DOI: 10.1021/jm0506930

Experimental method

X-RAY DIFFRACTION (2.28 Å)