3KLI

Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase

Summary for 3KLI

• Entry DOI: 10.2210/pdb3kli/pdb
• Related: 3KLE 3KLF 3KLG 3KLH
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT (3 entities in total)
• Functional Keywords: reverse transcriptase, azt resistance mechanism, p51/p66, hetero dimer, nucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, multifunctional enzyme, azt, azt resistance, transferase, nrti, azt resistance mutations
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 115882.88

Authors

Tu, X.,Sarafianos, S.G.,Arnold, E. (deposition date: 2009-11-08, release date: 2010-09-22, Last modification date: 2023-09-06)

• Primary citation: Tu, X.,Das, K.,Han, Q.,Bauman, J.D.,Clark, A.D.,Hou, X.,Frenkel, Y.V.,Gaffney, B.L.,Jones, R.A.,Boyer, P.L.,Hughes, S.H.,Sarafianos, S.G.,Arnold, E.; Structural basis of HIV-1 resistance to AZT by excision.; Nat.Struct.Mol.Biol., 17:1202-1209, 2010; PubMed: 20852643; DOI: 10.1038/nsmb.1908

Experimental method

X-RAY DIFFRACTION (2.65 Å)